Tag Archives: Transgenic Mice

Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington’s disease

Simone Rolfes et al. Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington’s disease. Neurobiology of Disease. Publication Date July 20, 2020 How Analyze was Used “Regions of interest (ROIs) were manually delineated onto T2*-weighted images according to Paxinos and Franklin mouse brain atlas (2007) for…

Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice

Arezoo Daryadel et al. Elevated FGF23 and disordered renal mineral handling with reduced bone mineralization in chronically erythropoietin over-expressing transgenic mice. Scientific Reports. Publication Date October 18, 2019 How Analyze was Used “All images were reconstructed and processed for bone analysis applying a commercially available software (Analyze 12.0, AnalyzeDirect, Inc., Overland Park, KS). A segment…

Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer’s disease transgenic mice using magnetic resonance microimaging

Wadghiri YZ, Li J, Wang J, Hoang DM, Sun Y, Xu H, Tsui W, Li Y, Boutajangout A, Wang A, de Leon M, Wisniewski T. Detection of amyloid plaques targeted by bifunctional USPIO in Alzheimer’s disease transgenic mice using magnetic resonance microimaging. PLoS One. February 2013;8(2):e57097. Full Text – Open Access Publication Date February 2013…

Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO

Stubbe T, Ebner F, Richter D, Engel O, Klehmet J, Royl G, Meisel A, Nitsch R, Meisel C, Brandt C. Regulatory T cells accumulate and proliferate in the ischemic hemisphere for up to 30 days after MCAO. J Cereb Blood Flow Metab. January 2013;33(1):37-47. Full Text – Open Access Publication Date January 2013 How Analyze…

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer’s disease

Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J, Siddiqui A, Tamura Y, Sesaki H, Wengenack TM, Dzeja PP, Poduslo JF. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer’s disease. PLoS One. February 2012;7(2):e32737. Full Text – Open Access Publication Date February 2012…

In vivo magnetic resonance imaging of amyloid-beta plaques in mice

Wadghiri YZ, Hoang DM, Wisniewski T, Sigurdsson EM. In vivo magnetic resonance imaging of amyloid-beta plaques in mice. Methods Mol Biol. January 2012;849:435-451. Full Text – Open Access Publication Date January 2012 How Analyze was Used “When combined with fast gradient-echo imaging sequences such as fast low-angle shot (FLASH) [McGown et al. 2006], whole 3D…

Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies

Lee EC, Fitzgerald M, Bannerman B, Donelan J, Bano K, Terkelsen J, Bradley DP, Subakan O, Silva MD, Liu R, Pickard M, Li Z, Tayber O, Li P, Hales P, Carsillo M, Neppalli VT, Berger AJ, Kupperman E, Manfredi M, Bolen JB, Van Ness B, Janz S. Antitumor activity of the investigational proteasome inhibitor MLN9708…

Deficits in spatial learning and memory is associated with hippocampal volume loss in aged apolipoprotein E4 mice

Yin JX, Turner GH, Lin HJ, Coons SW, Shi J. Deficits in spatial learning and memory is associated with hippocampal volume loss in aged apolipoprotein E4 mice. J Alzheimers Dis. July 2011;27(1):89-98. Publication Date July 2011 How Analyze was Used “To calculate volume, regions of interest (ROI) were manually traced for the whole brain, cortex,…

Detection of amyloid plaques targeted by USPIO-Aß1-42 in Alzheimer’s disease transgenic mice using magnetic resonance microimaging

Yang J, Wadghiri YZ, Hoang DM, Tsui W, Sun Y, Chung E, Li Y, Wang A, de Leon M, Wisniewski T. Detection of amyloid plaques targeted by USPIO-Aß1-42 in Alzheimer’s disease transgenic mice using magnetic resonance microimaging. Neuroimage. April 2011;55(4):1600-1609. Full Text – Open Access Publication Date April 2011 How Analyze was Used “The advantage…

Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain

Wengenack TM, Reyes DA, Curran GL, Borowski BJ, Lin J, Preboske GM, Holasek SS, Gilles EJ, Chamberlain R, Marjanska M, Jack CR, Jr., Garwood M, Poduslo JF. Regional differences in MRI detection of amyloid plaques in AD transgenic mouse brain. Neuroimage. January 2011;54(1):113-122. Full Text – Open Access Publication Date January 2011 How Analyze was…