AnalyzeDirect Wadghiri YZ, Hoang DM, Wisniewski T, Sigurdsson EM. In vivo magnetic resonance imaging of amyloid-beta plaques in mice. Methods Mol Biol. January 2012;849:435-451.
Full Text – Open Access
Publication Date
January 2012
How Analyze was Used
“When combined with fast gradient-echo imaging sequences such as fast low-angle shot (FLASH) [McGown et al. 2006], whole 3D mouse head datasets can be practically implemented, with a 100 μm isotropic resolution, in less than 2 h as described below. This eases both the co-registration of serial MRI scans and with histologically stained sections for retrospective realignment using either the public domain program ImageJ … or commercially available imaging packages such as Analyze (AnalyzeDirect, Inc., Overland Park, KS, USA).”
Keywords
Amyloid beta-Peptides/chemistry/metabolism
Animals
Brain/metabolism/pathology
Contrast Media/chemistry/diagnostic use
Gadolinium/chemistry
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging (MRI)/methods
Mannitol/diagnostic use
Mice
Mice, Transgenic
Plaque, Amyloid/diagnosis/metabolism/pathology
Putrescine/metabolism
Staining and Labeling
Author Affiliation(s)
Department of Radiology, Center for Biomedical Imaging New York University School of Medicine, New York, NY, US. (YZW, DMH)
Departments of Neurology, Pathology and Psychiatry, New York University School of Medicine, New York, NY, US. (TW)
Departments of Physiology and Neuroscience, and Psychiatry, New York University School of Medicine, New York, NY, US. (EMS)
ID# 632
Tags: Amyloid beta-Peptides/chemistry/metabolism, Amyloid Plaque/diagnosis/metabolism/pathology, Animals, Brain/metabolism/pathology, Contrast Media/chemistry/diagnostic use, Gadolinium/chemistry, Humans, Magnetic Resonance Imaging (MRI)/methods, Mannitol/diagnostic use, Mice, Putrescine/metabolism, Staining and Labeling, Three-Dimensional Imaging, Transgenic Mice