AnalyzeDirect

Analyze Publications Database

Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies

Lee EC, Fitzgerald M, Bannerman B, Donelan J, Bano K, Terkelsen J, Bradley DP, Subakan O, Silva MD, Liu R, Pickard M, Li Z, Tayber O, Li P, Hales P, Carsillo M, Neppalli VT, Berger AJ, Kupperman E, Manfredi M, Bolen JB, Van Ness B, Janz S. Antitumor activity of the investigational proteasome inhibitor MLN9708 in mouse models of B-cell and plasma cell malignancies. Clin Cancer Res. December 2011;17(23):7313-7323.

Full Text – Open Access

Publication Date
December 2011

How Analyze was Used
“All renderings were analyzed with Analyze 4.0 software.”

Keywords
Animals
Antineoplastic Agents/pharmacokinetics/pharmacology
Boron Compounds/administration & dosage/pharmacokinetics/pharmacology
Boronic Acids/pharmacokinetics/pharmacology
Cell Line, Tumor
Glycine/administration & dosage/analogs & derivatives/pharmacokinetics/pharmacology
Humans
Lymphoma, B-Cell/drug therapy/metabolism
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Mice, SCID
Mice, Transgenic
Neoplasms, Plasma Cell/drug therapy/metabolism
Osteolysis/drug therapy/etiology
Protease Inhibitors/pharmacology
Proteasome Inhibitors
Pyrazines/pharmacokinetics/pharmacology
Xenograft Model Antitumor Assays

Author Affiliation(s)
Millennium Pharmaceuticals, Inc., Cambridge, MA, US. (ECL, MF, BB, JD, KB, JT, DPB, OS, MDS, RL MP, ZL, OT, PL, PH, MC, AJB, EK, MM, JBB)

Department of Pathology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, Iowa City, IA, US. (VTN, SJ)

Department of Genetics, Cell Biology & Development, Institute of Human Genetics, University of Minnesota, Minneapolis, MN, US. (BVN)

ID# 1943

Tags: , , , , , , , , , , , , , , , , , ,