Tag Archives: Drug Dose-Response Relationship

Rationale and design of the DIPAK 1 study: a randomized controlled clinical trial assessing the efficacy of lanreotide to halt disease progression in autosomal dominant polycystic kidney disease

Meijer E, Drenth JP, d’Agnolo H, Casteleijn NF, de Fijter JW, Gevers TJ, Kappert P, Peters DJ, Salih M, Soonawala D, Spithoven EM, Torres VE, Visser FW, Wetzels JF, Zietse R, Gansevoort RT. Rationale and design of the DIPAK 1 study: a randomized controlled clinical trial assessing the efficacy of lanreotide to halt disease progression…

Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia

Malchow B, Hasan A, Schneider-Axmann T, Jatzko A, Gruber O, Schmitt A, Falkai P, Wobrock T. Effects of cannabis and familial loading on subcortical brain volumes in first-episode schizophrenia. Eur Arch Psychiatry Clin Neurosci. November 2013;263 Suppl 2:S155-168. Publication Date November 2013 How Analyze was Used “Manual area measurements were obtained by manual tracing of…

Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice

Simmons BH, Lee JH, Lalwani K, Giddabasappa A, Snider BA, Wong A, Lappin PB, Eswaraka J, Kan JL, Christensen JG, Shojaei F. Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice. Cancer Chemother Pharmacol. August 2012;70(2):213-220. Full Text – Open Access Publication Date…

Age-dependent renal cortical microvascular loss in female mice

Urbieta-Caceres VH, Syed FA, Lin J, Zhu XY, Jordan KL, Bell CC, Bentley MD, Lerman A, Khosla S, Lerman LO. Age-dependent renal cortical microvascular loss in female mice. Am J Physiol Endocrinol Metab. April 2012;302(8):E979-986. Full Text – Open Access Publication Date April 2012 How Analyze was Used “Three-dimensional volume images were reconstructed and analyzed…

Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study

Egerton A, Shotbolt JP, Stokes PRA, Hirani E, Ahmad R, Lappin JM, Reeves SJ, Mehta MA, Howes OD, Grasby PM. Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study. Neuroimage. March 2010;50(1):260-266. Full Text – Open Access Publication Date March 2010 How Analyze was Used…

Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension

Lin J, Zhu X, Chade AR, Jordan KL, Lavi R, Daghini E, Gibson ME, Guglielmotti A, Lerman A, Lerman LO. Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension. Arterioscler Thromb Vasc Biol. November 2009;29(11):1810-1816. Full Text – Open Access Publication Date November 2009 How Analyze was Used “Pigs were scanned by either…

Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model

Katsanos K, Karnabatidis D, Diamantopoulos A, Kagadis GC, Ravazoula P, Nikiforidis GC, Siablis D, Tsopanoglou NE. Thrombin promotes arteriogenesis and hemodynamic recovery in a rabbit hindlimb ischemia model. J Vasc Surg. April 2009;49(4):1000-1012. Full Text – Open Access Publication Date April 2009 How Analyze was Used “Images were further analyzed and postprocessed with the Analyze…

SB 234551 selective ETA receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection

Legos JJ, Lenhard SC, Haimbach RE, Schaeffer TR, Bentley RG, McVey MJ, Chandra S, Irving EA, Andrew AP, Barone FC. SB 234551 selective ETA receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection. Exp Neurol. July 2008;212(1):53-62. Publication Date July 2008 How Analyze was Used “All MR…

Dopamine D2 receptor occupancy levels of acute sulpiride challenges that produce working memory and learning impairments in healthy volunteers

Mehta MA, Montgomery AJ, Kitamura Y, Grasby PM. Dopamine D2 receptor occupancy levels of acute sulpiride challenges that produce working memory and learning impairments in healthy volunteers. Psychopharmacology (Berl). January 2008;196(1):157-165. Publication Date January 2008 How Analyze was Used “An ROI for the region of the substantia nigra was based on a template developed in…

Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity

Pasarica M, Zachwieja JJ, Dejonge L, Redman S, Smith SR. Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity. J Clin Endocrinol Metab. November 2007;92(11):4265-4270. Full Text – Open Access Publication Date November 2007 How Analyze was Used “Images were analyzed using an off-scanner image analysis program (AnalyzePC;…