AnalyzeDirect Urbieta-Caceres VH, Syed FA, Lin J, Zhu XY, Jordan KL, Bell CC, Bentley MD, Lerman A, Khosla S, Lerman LO. Age-dependent renal cortical microvascular loss in female mice. Am J Physiol Endocrinol Metab. April 2012;302(8):E979-986.
Full Text – Open Access
Publication Date
April 2012
How Analyze was Used
“Three-dimensional volume images were reconstructed and analyzed with the Analyze software package… The spatial density of renal cortical microvessels (20–500 μm) was then determined in 12 equidistant slices in each cortex, as described.”
Keywords
Adrenal Cortex/blood supply/drug effects/metabolism/pathology
Aging
Animals
Dose-Response Relationship, Drug
Estradiol/administration & dosage/analogs & derivatives/pharmacology
Estrogen Replacement Therapy
Female
Fibrosis
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Mice
Mice, Inbred C57BL
Microvessels/anatomy & histology/drug effects/metabolism
Ovariectomy
Oxidative Stress/drug effects
Postmenopause
Signal Transduction/drug effects
Transforming Growth Factor beta/metabolism
X-Ray Microtomography
Author Affiliation(s)
Divisionsof Nephrology and Hypertension, Mayo Clinic, Rochester, MN, US. (VHUC, JL, XYZ, KLJ, CCB, LOL)
Divison of Endocrinology, Mayo Clinic, Rochester, MN, US. (FAS, SK)
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, US. (AL, LOL)
Department of Biological Sciences, Minnesota State University, Mankato, MN, US. (MDB)
ID# 526
Tags: Adrenal Cortex/blood supply/drug effects/metabolism/pathology, Aging, Animals, Computer-Assisted Image Processing, Drug Dose-Response Relationship, Estradiol/administration & dosage/analogs & derivatives/pharmacology, Estrogen Replacement Therapy, Female, Fibrosis, Inbred C57BL Mice, Mice, Microvessels/anatomy & histology/drug effects/metabolism, Ovariectomy, Oxidative Stress/drug effects, Postmenopause, Signal Transduction/drug effects, Three-Dimensional Imaging, Transforming Growth Factor beta/metabolism, X-Ray Microtomography