AnalyzeDirect Simmons BH, Lee JH, Lalwani K, Giddabasappa A, Snider BA, Wong A, Lappin PB, Eswaraka J, Kan JL, Christensen JG, Shojaei F. Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice. Cancer Chemother Pharmacol. August 2012;70(2):213-220.
Full Text – Open Access
Publication Date
August 2012
How Analyze was Used
“Images were saved as 2D binary digital imaging communication (DICOM) files and later were analyzed using third-party DICOM image processing applications 64-bit OsiriX v3.9.2 (Pixmeo; Switzerland) and/or Analyze v.10.0 (AnalyzeDirect; Overland Park, KS, USA).”
Keywords
Adenocarcinoma/drug therapy/enzymology
Animals
Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse
effects/pharmacology/therapeutic use
Benzamides/administration & dosage
Cell Line, Tumor
Diphenylamine/administration & dosage/analogs & derivatives
Dose-Response Relationship, Drug
Heterozygote
Humans
Lung Neoplasms/drug therapy/enzymology
Maximum Tolerated Dose
Mice
Mice, Mutant Strains
Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors
Neoplasm Transplantation
Phosphatidylinositol 3-Kinase/antagonists & inhibitors
Proto-Oncogene Proteins p21(ras)/genetics
Pyridones/administration & dosage
Pyrimidines/administration & dosage
TOR Serine-Threonine Kinases/antagonists & inhibitors
Author Affiliation(s)
Oncology Research Unit, Pfizer Global R&D, 10724 Science Center Dr., La Jolla, San Diego, CA, 92121, US. (BHS, JHL, JLK, JGC, FS)
Department of Comparative Medicine, Pfizer Global R&D, 10724 Science Center Dr., La Jolla, San Diego, CA, 92121, US. (KL, AG, JE)
Department of Drug Safety Research & Development, Pfizer Global R&D, 10724 Science Center Dr., La Jolla, San Diego, CA, 92121, US. (BAS, AW, PBL)
ID# 553
Tags: Adenocarcinoma/drug therapy/enzymology, Animals, Antineoplastic Combined Chemotherapy Protocols/administration & dosage/adverse effects/pharmacology/therapeutic use, Benzamides/administration & dosage, Diphenylamine/administration & dosage/analogs & derivatives, Drug Dose-Response Relationship, Heterozygote, Humans, Lung Neoplasms/drug therapy/enzymology, Maximum Tolerated Dose, Mice, Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors, Mutant Strains Mice, Neoplasm Transplantation, Phosphatidylinositol 3-Kinase/antagonists & inhibitors, Proto-Oncogene Proteins p21(ras)/genetics, Pyridones/administration & dosage, Pyrimidines/administration & dosage, TOR Serine-Threonine Kinases/antagonists & inhibitors, Tumor Cell Line