Tag Archives: Drug Dose-Response Relationship

PPARδ activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure

Jucker BM, Doe CP, Schnackenberg CG, Olzinski AR, Maniscalco K, Williams C, Hu TC, Lenhard SC, Costell M, Bernard R, Sarov-Blat L, Steplewski K, Willette RN. PPARδ activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure. J Cardiovasc Pharmacol. July 2007;50(1):25-34. Publication Date July 2007 How Analyze was Used “The…

Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress

Galili O, Versari D, Sattler KJ, Olson ML, Mannheim D, McConnell JP, Chade AR, Lerman LO, Lerman A. Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress. Am J Physiol Heart Circ Physiol. February 2007;292(2):H904-911. Full Text – Open Access Publication Date February 2007 How Analyze was Used “For each pig, five…

In vivo evidence that 5-HT2C receptors inhibit 5-HT neuronal activity via a GABAergic mechanism

Boothman L, Raley J, Denk F, Hirani E, Sharp T. In vivo evidence that 5-HT2C receptors inhibit 5-HT neuronal activity via a GABAergic mechanism. Br J Pharmacol. December 2006;149(7):861-869. Full Text – Open Access Publication Date December 2006 How Analyze was Used “Data were transferred into ANALYZE-AVW imaging software and a standard volume of interest (VOI)…

Phase II trial of pirfenidone in adults with neurofibromatosis type 1

Babovic-Vuksanovic D, Ballman K, Michels V, McGrann P, Lindor N, King B, Camp J, Micic V, Babovic N, Carrero X, Spinner R, O’Neill B. Phase II trial of pirfenidone in adults with neurofibromatosis type 1. Neurology. November 2006;67(10):1860-1862. Publication Date November 2006 How Analyze was Used “Tumor volumes were determined by standard perimeter tracing and…

IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis

Schopf L, Savinainen A, Anderson K, Kujawa J, DuPont M, Silva M, Siebert E, Chandra S, Morgan J, Gangurde P, Wen D, Lane J, Xu Y, Hepperle M, Harriman G, Ocain T, Jaffee B. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum. October 2006;54(10):3163-3173. Full Text…

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus

Merchant M, Evangelista M, Luoh SM, Frantz GD, Chalasani S, Carano RAD, van Hoy M, Ramirez J, Ogasawara AK, McFarland LM, Filvaroff EH, French DM, de Sauvage FJ. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol. August 2005;25(16):7054-7068. Full Text – Open Access…

Tumor vascular response to photodynamic therapy and the antivascular agent 5,6-dimethylxanthenone-4-acetic acid: implications for combination therapy

Seshadri M, Spernyak JA, Mazurchuk R, Camacho SH, Oseroff AR, Cheney RT, Bellnier DA. Tumor vascular response to photodynamic therapy and the antivascular agent 5,6-dimethylxanthenone-4-acetic acid: implications for combination therapy. Clin Cancer Res. June 2005;11(11):4241-4250. Full Text – Open Access Publication Date June 2005 How Analyze was Used “Image analysis and three-dimensional renderings were done…

The effects of early lead exposure on the brains of adult rhesus monkeys: a volumetric MRI study

Lasky RE, Luck ML, Parikh NA, Laughlin NK. The effects of early lead exposure on the brains of adult rhesus monkeys: a volumetric MRI study. Toxicol Sci. June 2005;85(2):963-975. Full Text – Open Access Publication Date June 2005 How Analyze was Used “The volumetric measurements were performed by R.E.L. using ANALYZE software (version 4.0).” Keywords…

A functional aquaporin co-localizes with the vacuolar proton pyrophosphatase to acidocalcisomes and the contractile vacuole complex of Trypanosoma cruzi

Montalvetti A, Rohloff P, Docampo R. A functional aquaporin co-localizes with the vacuolar proton pyrophosphatase to acidocalcisomes and the contractile vacuole complex of Trypanosoma cruzi. J Biol Chem. September 2004;279(37):38673-38682. Full Text – Open Access Publication Date September 2004 How Analyze was Used “The surface area of the sequential images was calculated using AnalyzeAVW version…

Effect of oral CCK-1 agonist GI181771X on fasting and postprandial gastric functions in healthy volunteers

Castillo EJ, Delgado-Aros S, Camilleri M, Burton D, Stephens D, O’Connor-Semmes R, Walker A, Shachoy-Clark A, Zinsmeister AR. Effect of oral CCK-1 agonist GI181771X on fasting and postprandial gastric functions in healthy volunteers. Am J Physiol Gastrointest Liver Physiol. August 2004;287(2):G363-369. Full Text – Open Access Publication Date August 2004 How Analyze was Used “Stomach…