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Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress

Galili O, Versari D, Sattler KJ, Olson ML, Mannheim D, McConnell JP, Chade AR, Lerman LO, Lerman A. Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress. Am J Physiol Heart Circ Physiol. February 2007;292(2):H904-911.

Full Text – Open Access

Publication Date
February 2007

How Analyze was Used
“For each pig, five EBCT-derived cross-sections (at the level of renal hilum) were analyzed to estimate the amount of intra-abdominal fat tissue [Shen et al. 2003, Snell-Burgeon et al. 2004]. With the use of image analysis software (Analyze …), the density range of subcutaneous fat tissue was used to automatically threshold the adipose tissue in the entire image.”

Keywords
Animals
Blood Pressure
Capillary Permeability
Coronary Vessels/drug effects/metabolism/physiopathology
Dietary Fats
Dinoprost/analogs & derivatives/blood
Disease Models, Animal
Dose-Response Relationship, Drug
Endothelium, Vascular/drug effects/metabolism/physiopathology
Female
Hypertension/etiology/physiopathology
Intra-Abdominal Fat/pathology
Leptin/blood
Lipids/blood
Microcirculation/metabolism/physiopathology
Nitric Oxide/metabolism
Obesity/complications/metabolism/pathology/physiopathology
Oxidative Stress
Random Allocation
Superoxides/metabolism
Swine
Tomography, X-Ray Computed
Vasoconstrictor Agents/pharmacology
Vasodilator Agents/pharmacology

Author Affiliation(s)
Department of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, MN, US. (OG, DV, KJS, MLO, DM, LOL, AL)

Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, US. (JPM)

Department of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN, US. (ARC, LOL)

ID# 1700

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