AnalyzeDirect

Jucker BM, Doe CP, Schnackenberg CG, Olzinski AR, Maniscalco K, Williams C, Hu TC, Lenhard SC, Costell M, Bernard R, Sarov-Blat L, Steplewski K, Willette RN. PPARδ activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure. J Cardiovasc Pharmacol. July 2007;50(1):25-34.

Publication Date
July 2007

How Analyze was Used
“The imaging parameters were as follows: matrix dimensions, 128 × 128; TR/TE, 20/3.7 ms; slice thickness, 2.0 mm; FOV, 5.0 cm; 4 averages; sine loop, 10 images. Left ventricle (LV) functional parameters were analyzed (Analyze AVW software, AnalyzeDirect, Lenexa, KS).”

Keywords
Animals
Biological Transport
Diuresis/drug effects
Dose-Response Relationship, Drug
Energy Metabolism
Gene Expression/drug effects
Heart Failure/drug therapy/etiology/physiopathology
Hypertrophy, Right Ventricular/drug therapy/etiology/physiopathology
Lipids/blood
Magnetic Resonance Spectroscopy
Male
Myocardial Infarction/complications
Oxidation-Reduction
PPAR delta/agonists/metabolism
Pulmonary Edema/drug therapy/etiology
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Ventricular Function, Left/drug effects

Author Affiliation(s)
Cardiovascular and Urogenital Center of Excellence for Drug Discovery, and Genomics Research, GlaxoSmithKline, King of Prussia, PA 19406, US.

ID# 1696

Tags: Animals, Biological Transport, Diuresis/drug effects, Drug Dose-Response Relationship, Energy Metabolism, Gene Expression/drug effects, Heart Failure/drug therapy/etiology/physiopathology, Left/drug effects, Lipids/blood, Magnetic Resonance Spectroscopy, Male, Myocardial Infarction/complications, Oxidation-Reduction, PPAR delta/agonists/metabolism, Pulmonary Edema/drug therapy/etiology, Rats, Reverse Transcriptase Polymerase Chain Reaction, Right Ventricular Hypertrophy/drug therapy/etiology/physiopathology, Sprague-Dawley Rats, Ventricular Function