AnalyzeDirect Legos JJ, Lenhard SC, Haimbach RE, Schaeffer TR, Bentley RG, McVey MJ, Chandra S, Irving EA, Andrew AP, Barone FC. SB 234551 selective ETA receptor antagonism: perfusion/diffusion MRI used to define treatable stroke model, time to treatment and mechanism of protection. Exp Neurol. July 2008;212(1):53-62.
Publication Date
July 2008
How Analyze was Used
“All MR images were transferred to an SGI UNIX workstation and were analyzed with the software package ANALYZE™ (AnalyzeDirect.com).”
Keywords
Animals
Brain/drug effects/pathology/physiopathology
Brain Infarction/drug therapy/pathology/physiopathology
Cerebral Arteries/drug effects/metabolism/physiopathology
Cerebrovascular Circulation/drug effects/physiology
Diffusion Magnetic Resonance Imaging/methods
Dioxoles/pharmacology/therapeutic use
Disease Models, Animal
Dose-Response Relationship, Drug
Emergency Medical Services/standards
Endothelin A Receptor Antagonists
Infarction, Middle Cerebral Artery/drug therapy/metabolism/physiopathology
Male
Neuroprotective Agents/pharmacology/therapeutic use
Pyrazoles/pharmacology/therapeutic use
Rats
Rats, Inbred SHR
Rats, Sprague-Dawley
Receptor, Endothelin A/metabolism
Stroke/drug therapy/pathology/physiopathology
Time Factors
Treatment Outcome
Author Affiliation(s)
High Throughput Biology, Discovery Research, King of Prussia, PA, US. (JJL, MJM, FCB)
Cardiovascular and Urogenital Center of Excellence for Drug Discovery, King of Prussia, PA, US. (SCL, REH, RCB)
Laboratory Animal Sciences, King of Prussia, PA, US. (TRS)
Technology Development, GlaxoSmithKline, King of Prussia, PA, US. (SC)
Neurology Center of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, UK. (EAI, AAP)
ID# 1566
Tags: Animal Disease Models, Animals, Brain Infarction/drug therapy/pathology/physiopathology, Brain/drug effects/pathology/physiopathology, Cerebral Arteries/drug effects/metabolism/physiopathology, Cerebrovascular Circulation/drug effects/physiology, Diffusion Magnetic Resonance Imaging/methods, Dioxoles/pharmacology/therapeutic use, Drug Dose-Response Relationship, Emergency Medical Services/standards, Endothelin A Receptor Antagonists, Endothelin A Receptor/metabolism, Inbred SHR Rats, Male, Middle Cerebral Artery Infarction/drug therapy/metabolism/physiopathology, Neuroprotective Agents/pharmacology/therapeutic use, Pyrazoles/pharmacology/therapeutic use, Rats, Sprague-Dawley Rats, Stroke/drug therapy/pathology/physiopathology, Time Factors, Treatment Outcome