Tag Archives: Animal Disease Models

Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression

Seeger FH, Sedding D, Langheinrich AC, Haendeler J, Zeiher AM, Dimmeler S. Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression. Basic Res Cardiol. May 2010;105(3):389-397. Publication Date May 2010 How Analyze was Used “For better anatomical orientation, the aorta and the heart…

Brain phenotypes in two FGFR2 mouse models for Apert syndrome

Aldridge K, Hill CA, Austin JR, Percival C, Martinez-Abadias N, Neuberger T, Wang Y, Jabs EW, Richtsmeier JT. Brain phenotypes in two FGFR2 mouse models for Apert syndrome. Dev Dyn. March 2010;239(3):987-997. Full Text – Open Access Publication Date March 2010 How Analyze was Used “The 3D coordinate locations of neuroanatomical landmarks were recorded for…

Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease

Stroope A, Radtke B, Huang B, Masyuk T, Torres V, Ritman E, LaRusso N. Hepato-renal pathology in pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease. Am J Pathol. March 2010;176(3):1282-1291. Full Text – Open Access Publication Date March 2010 How Analyze was Used “Specimens were scanned using a micro-computed tomography (CT) scanner….

Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment

Olzinski AR, Turner GH, Bernard RE, Karr H, Cornejo CA, Aravindhan K, Hoang B, Ringenberg MA, Qin P, Goodman KB, Willette RN, Macphee CH, Jucker BM, Sehon CA, Gough PJ. Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance…

A human brainstem glioma xenograft model enabled for bioluminescence imaging

Hashizume R, Ozawa T, Dinca EB, Banerjee A, Prados MD, James CD, Gupta N. A human brainstem glioma xenograft model enabled for bioluminescence imaging. J Neurooncol. January 2010;96(2):151-159. Full Text – Open Access Publication Date January 2010 How Analyze was Used “For the volumetric assessment of intracranial tumor, tumor regions were identified on serially-sectioned H&E…

FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis

Davies JR, Izquierdo-Garcia D, Rudd JHF, Figg N, Richards HK, Bird JL, Aigbirhio FI, Davenport AP, Weissberg PL, Fryer TD, Warburton EA. FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis. Int J Cardiovasc Imaging. January 2010;26(1):41-48. Publication Date January 2010 How Analyze was Used “Quantification of FDG concentration in the…

Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia

Gössl M, Herrmann J, Tang H, Versari D, Galili O, Mannheim D, Rajkumar SV, Lerman LO, Lerman A. Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia. Basic Res Cardiol. November 2009;104(6):695-706. Full Text – Open Access Publication Date November 2009 How Analyze was Used “The resulting 3D images were displayed using…

Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension

Lin J, Zhu X, Chade AR, Jordan KL, Lavi R, Daghini E, Gibson ME, Guglielmotti A, Lerman A, Lerman LO. Monocyte chemoattractant proteins mediate myocardial microvascular dysfunction in swine renovascular hypertension. Arterioscler Thromb Vasc Biol. November 2009;29(11):1810-1816. Full Text – Open Access Publication Date November 2009 How Analyze was Used “Pigs were scanned by either…

Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus

Lee MJ, Chang CP, Lee YH, Wu YC, Tseng HW, Tung YY, Wu MT, Chen YH, Kuo LT, Stephenson D, Hung SI, Wu JY, Chang C, Chen YT, Chern Y. Longitudinal evaluation of an N-ethyl-N-nitrosourea-created murine model with normal pressure hydrocephalus. PLoS One. November 2009;4(11):e7868. Full Text – Open Access Publication Date November 2009 How…

Protein ubiquitination in postsynaptic densities after hypoxia in rat neostriatum is blocked by hypothermia

Capani F, Saraceno GE, Botti V, Aon-Bertolino L, de Oliveira DM, Barreto G, Galeano P, Giraldez-Alvarez LD, Coirini H. Protein ubiquitination in postsynaptic densities after hypoxia in rat neostriatum is blocked by hypothermia. Exp Neurol. October 2009;219(2):404-413. Publication Date October 2009 How Analyze was Used “Final volumes were observed and segmentated using the program ANALYZE.”…