AnalyzeDirect Olzinski AR, Turner GH, Bernard RE, Karr H, Cornejo CA, Aravindhan K, Hoang B, Ringenberg MA, Qin P, Goodman KB, Willette RN, Macphee CH, Jucker BM, Sehon CA, Gough PJ. Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment. Arterioscler Thromb Vasc Biol. February 2010;30(2):253-259.
Full Text – Open Access*
*See Data Supplement for Analyze information
Publication Date
February 2010
How Analyze was Used
“All images were analyzed using Analyze AVW software (AnalyzeDirect, Lenexa, KS). Images were reconstructed to 512 pixels x 512 pixels prior to semi-automated trace analysis.”
Keywords
Angiotensin II/administration & dosage
Animals
Anti-Inflammatory Agents/pharmacokinetics/pharmacology
Aortic Diseases/diet therapy/immunology/pathology
Apolipoproteins E/deficiency/genetics
Atherosclerosis/drug therapy/immunology/pathology
Contrast Media/diagnostic use
Dextrans/diagnostic use
Dietary Fats/administration & dosage
Disease Models, Animal
Ferrosoferric Oxide/diagnostic use
Humans
Immunohistochemistry
Infusion Pumps, Implantable
Macrophages/drug effects/immunology/pathology
Magnetic Resonance Imaging (MRI)
Magnetite Nanoparticles
Mice
Mice, Knockout
Mice, Transgenic
Naphthyridines/pharmacokinetics/pharmacology
Peritonitis/immunology/prevention & control
Receptors, CCR2/antagonists & inhibitors/genetics/metabolism
Time Factors
Author Affiliation(s)
Cardiovascular and Urogenital Center of Excellence in Drug Discovery, King of Prussia, PA. (ARO, GHT, REB, HK, CAC, KA, PQ, KBG, RNW, CHM, BMJ, CAS, PJG)
Discovery Technology Group, King of Prussia, PA. (BH)
Safety Assessment, GlaxoSmithKline, King of Prussia, PA. (MAR)
ID# 1155
Tags: Angiotensin II/administration & dosage, Animal Disease Models, Animals, Anti-Inflammatory Agents/pharmacokinetics/pharmacology, Aortic Diseases/diet therapy/immunology/pathology, Apolipoproteins E/deficiency/genetics, Atherosclerosis/drug therapy/immunology/pathology, CCR2 Receptors/antagonists & inhibitors/genetics/metabolism, Contrast Media/diagnostic use, Dextrans/diagnostic use, Dietary Fats/administration & dosage, Ferrosoferric Oxide/diagnostic use, Humans, Immunohistochemistry, Implantable Infusion Pumps, Knockout Mice, Macrophages/drug effects/immunology/pathology, Magnetic Resonance Imaging (MRI), Magnetite Nanoparticles, Mice, Naphthyridines/pharmacokinetics/pharmacology, Peritonitis/immunology/prevention & control, Time Factors, Transgenic Mice