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Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression

Seeger FH, Sedding D, Langheinrich AC, Haendeler J, Zeiher AM, Dimmeler S. Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression. Basic Res Cardiol. May 2010;105(3):389-397.

Publication Date
May 2010

How Analyze was Used
“For better anatomical orientation, the aorta and the heart were scanned en bloc by a micro-CT system described recently. The resulting 3D images were displayed using image analysis software (Analyze® 6.0).”

Keywords
Animals
Apolipoproteins E/genetics/metabolism
Atherosclerosis/etiology/prevention & control
Disease Models, Animal
Disease Progression
Enzyme Inhibitors/pharmacology
Hypercholesterolemia/complications
Imidazoles/pharmacology
Mesenchymal Stromal Cells/cytology/drug effects/physiology
Mice
Mice, Knockout
Neovascularization, Physiologic/drug effects/physiology
Phosphorylation/drug effects/physiology
Pyridines/pharmacology
p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors

Author Affiliation(s)
Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Universität Frankfurt, Haus 25, 4. Stock, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. (FHS, DS)

Department of Cardiology, Internal Medicine III, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany. (FHS, AMZ)

Department of Internal Medicine/Cardiology, University of Giessen and Marburg GmbH, Giessen, Germany. (DS)

Department of Diagnostic Radiology, University of Giessen & Marburg GmbH, Giessen, Germany. (ACL)

Molecular Cell & Aging Research, IUF (Institute for Preventive Medicine) at the University of Duesseldorf gGmbH, Düsseldorf, Germany. (JH)

ID# 1058

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