Tag Archives: Drug Discovery

Development of a miniaturized 96-Transwell air–liquid interface human small airway epithelial model

Teresa Bluhmki et al. Development of a miniaturized 96-Transwell air–liquid interface human small airway epithelial model. Scientific Reports. Publication Date August 3, 2020 How Analyze was Used “Visualization of the image stacks was performed using the Analyze software (AnalyzeDirect, Overland Park, KS). A grey value time course was calculated for each pixel over 512 frames…

Quantification of Lung Fibrosis in IPF-Like Mouse Model and Pharmacological Response to Treatment by Micro-Computed Tomography

Francesca Ruscitti et al. Quantification of Lung Fibrosis in IPF-Like Mouse Model and Pharmacological Response to Treatment by Micro-Computed Tomography. Frontiers in Pharmacology. Publication Date July 21, 2020 How Analyze was Used “For each examination, a stack of 512 cross-sectional images stored in unsigned 16-bit file format was produced. The reconstructed datasets were analyzed using…

Farnesoid X receptor activation inhibits TGFBR1/TAK1-mediated vascular inflammation and calcification via miR-135a-5p

Chao Li et al. Farnesoid X receptor activation inhibits TGFBR1/TAK1-mediated vascular inflammation and calcification via miR-135a-5p. Communications Biology. Publication Date June 24, 2020 How Analyze was Used “Pictures of the chest areas (including heart and thoracic aorta) of the rats were taken; the processing of the images and three-dimensional standard microstructural analysis were performed using…

In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT 1(A/B/D) receptor antagonist, GSK588045, using Positron Emission Tomography

Comley RA, van der Aart J, Gulyás B, Garnier M, Iavarone L, Halldin C, Rabiner EA. In vivo occupancy of the 5-HT1A receptor by a novel pan 5-HT 1(A/B/D) receptor antagonist, GSK588045, using Positron Emission Tomography. Neuropharmacology. December 2014. Publication Date December 2014 How Analyze was Used “To allow determination of regional radioligand binding, regions…

Sox2 cooperates with lkb1 loss in a mouse model of squamous cell lung cancer

Mukhopadhyay A, Berrett KC, Kc U, Clair PM, Pop SM, Carr SR, Witt BL, Oliver TG. Sox2 cooperates with lkb1 loss in a mouse model of squamous cell lung cancer. Cell Rep. May 2014;8(1):40-49. Full Text – Open Access Publication Date May 2014 How Analyze was Used “Images were acquired using PerkinElmer Quantum FX software…