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Comley RA, van der Aart J, Gulyás B, Garnier M, Iavarone L, Halldin C, Rabiner EA. In vivo occupancy of the 5-HT_1A receptor by a novel pan 5-HT _1(A/B/D) receptor antagonist, GSK588045, using Positron Emission Tomography. Neuropharmacology. December 2014.

Publication Date
December 2014

How Analyze was Used
“To allow determination of regional radioligand binding, regions of interest (ROIs) were manually delineated on integrated isotropic PET images (voxel size 1 x 1 x mm³) for each subject (Analyze version 4.0).”

Keywords
5-HT1 Receptors
Anti-Anxiety Agents
Antidepressive Agents
Drug Discovery
Positron-Emission Tomography (PET)

Author Affiliation(s)
Clinical Imaging Centre, GlaxoSmithKline, London, UK. (RAC, JA, EAR)

Psychiatry Centre for Excellence in Drug Discovery, GlaxoSmithKline, Verona, Italy. (MG, LL)

Department of Neuroscience, Karolinska Institute, Stockholm, Sweden. (BG, CH)

ID# 1085

Tags: 5-HT1 Receptors, Anti-Anxiety Agents, Antidepressive Agents, Drug Discovery, Positron Emission Tomography (PET)