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McGinnity CJ, Shidahara M, Feldmann M, Keihaninejad S, Riaño Barros DA, Gousias IS, Duncan JS, Brooks DJ, Heckemann RA, Turkheimer FE, Hammers A, Koepp MJ. Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [¹¹C]diprenorphine PET data for the partial-volume effect. Neuroimage. October 2013;79:72-80.

Publication Date
October 2013

How Analyze was Used
“First, each participant’s MR image was tissue-class segmented using SPM5 according to the Unified Segmentation method (Ashburner and Friston, 2005). The grey matter component was then thresholded at 50% probability using Analyze AVW 8.1.”

Keywords
Adult
Brain/metabolism/radionuclide imaging
Carbon Radioisotopes/diagnostic use/pharmacokinetics
Diprenorphine/diagnostic use/pharmacokinetics
Epilepsy/metabolism/radionuclide imaging
Female
Humans
Image Enhancement/methods
Image Interpretation, Computer-Assisted/methods
Imaging, Three-Dimensional/methods
Male
Metabolic Clearance Rate
Middle Aged
Positron-Emission Tomography/methods
Radiopharmaceuticals/diagnostic use/pharmacokinetics
Receptors, Opioid/metabolism
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution

Author Affiliation(s)
Centre for Neuroscience, Department of Medicine, Imperial College London, London W12 0NN, UK. (CJM, DARB, ISG, DJB, RAH, FET, AH)

Medical Research Council Clinical Sciences Centre, London W12 0NN, UK. (CJM, DARB, ISG, RAH, FET, AH)

Department of Clinical Neuroscience, Institute of Psychiatry, King’s College London, London SE5 8AF, UK. (CJM)

Division of Medical Physics, Tohoku University Graduate School of Medicine, Sendai, Japan. (MS)

Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, UK. (MF, JSD, AH, MJK)

Epilepsy Society, Chalfont St. Peter, Buckinghamshire SL9 0RJ, UK. (MF, JSD, AH, MJK)

Department of Neurodegenerative Diseases, Institute of Neurology, University College London, London WC1N 3BG, UK. (SK)

The Neurodis Foundation, CERMEP Imagerie du Vivant, 69003 Lyon, France. (RAH, AH)

Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London SE5 8AF, UK. (FET)

ID# 942

Tags: Adult, Brain/metabolism/radionuclide imaging, Carbon Radioisotopes/diagnostic use/pharmacokinetics, Computer-Assisted Image Interpretation/methods, Diprenorphine/diagnostic use/pharmacokinetics, Epilepsy/metabolism/radionuclide imaging, Female, Humans, Image Enhancement/methods, Male, Metabolic Clearance Rate, Middle Aged, Opioid Receptors/metabolism, Positron-Emission Tomography (PET)/methods, Radiopharmaceuticals/diagnostic use/pharmacokinetics, Reproducibility of Results, Sensitivity and Specificity, Three-Dimensional Imaging/methods, Tissue Distribution