Tag Archives: Radiopharmaceuticals/diagnostic use/pharmacokinetics

Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect

McGinnity CJ, Shidahara M, Feldmann M, Keihaninejad S, Riaño Barros DA, Gousias IS, Duncan JS, Brooks DJ, Heckemann RA, Turkheimer FE, Hammers A, Koepp MJ. Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect. Neuroimage. October 2013;79:72-80. Publication Date October 2013 How Analyze was Used “First,…

[18F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [18F]FDOPA and [11C]DASB PET study in Parkinson’s disease

Pavese N, Simpson BS, Metta V, Ramlackhansingh A, Chaudhuri KR, Brooks DJ. [18F]FDOPA uptake in the raphe nuclei complex reflects serotonin transporter availability. A combined [18F]FDOPA and [11C]DASB PET study in Parkinson’s disease. Neuroimage. January 2012;59(2):1080-1084. Publication Date January 2012 How Analyze was Used “Once in ANALYZE format the parametric Ki and ADD images generated…

Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain

Brinkmann BH, Jones DT, Stead M, Kazemi N, O’Brien TJ, So EL, Blumenfeld H, Mullan BP, Worrell GA. Statistical parametric mapping demonstrates asymmetric uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in normal brain. J Cereb Blood Flow Metab. January 2012;32(1):190-198. Full Text – Open Access Publication Date January 2012 How Analyze was Used “Post-acquisition…

Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest

del Campo N, Tait RJ, Acosta-Cabronero J, Hong YT, Izquierdo-Garcia D, Smith R, Aigbirhio FI, Sahakian BJ, Müller U, Robbins TW, Fryer TD. Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest. Neuroimage. March 2011;55(1):101-112. Publication Date March 2011 How Analyze was Used “Three-dimensional regions of interest were manually…

Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge

Stokes PRA, Egerton A, Watson B, Reid A, Breen G, Lingford-Hughes A, Nutt DJ, Mehta MA. Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge. Neuroimage. October 2010;52(4):1521-1527. Publication Date October 2010 How Analyze was Used “The ROIs were spatially normalised from standard space to individual space by applying the deformation matrix previously…

[18F]fluoromethyl-[1,2-2H4]-choline: a novel radiotracer for imaging choline metabolism in tumors by positron emission tomography

Leyton J, Smith G, Zhao Y, Perumal M, Nguyen QD, Robins E, Arstad E, Aboagye EO. [18F]fluoromethyl-[1,2-2H4]-choline: a novel radiotracer for imaging choline metabolism in tumors by positron emission tomography. Cancer Res. October 2009;69(19):7721-7728. Full Text – Open Access Publication Date October 2009 How Analyze was Used “The image data sets were visualized using the…

[11C]choline positron emission tomography in estrogen receptor-positive breast cancer

Contractor KB, Kenny LM, Stebbing J, Al-Nahhas A, Palmieri C, Sinnett D, Lewis JS, Hogben K, Osman S, Shousha S, Lowdell C, Coombes RC, Aboagye EO. [11C]choline positron emission tomography in estrogen receptor-positive breast cancer. Clin Cancer Res. September 2009;15(17):5503-5510. Full Text – Open Access Publication Date September 2009 How Analyze was Used “Regions of…

In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography

Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, Pillai R, He Q, Atadja P, Lam EWF, Workman P, Vigushin DM, Aboagye EO. In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography. Cancer Res. August 2006;66(15):7621-7629. Full Text – Open Access Publication Date…

Microglial activation correlates with severity in Huntington disease: a clinical and PET study

Pavese N, Gerhard A, Tai YF, Ho AK, Turkheimer F, Barker RA, Brooks DJ, Piccini P. Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology. June 2006;66(11):1638-1643. Publication Date June 2006 How Analyze was Used “The standard object map contained regions defined for hypothalamus, frontal, parietal, temporal, and occipital lobes…

Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson’s disease

Hu MTM, Scherfler C, Khan NL, Hajnal JV, Lees AJ, Quinn N, Wood NW, Brooks DJ. Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson’s disease. Mov Disord. March 2006;21(3):299-305. Publication Date March 2006 How Analyze was Used “These nigral images, thresholded to similar maximum and minimum intensities (5 and 0, respectively), were…