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Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge

Stokes PRA, Egerton A, Watson B, Reid A, Breen G, Lingford-Hughes A, Nutt DJ, Mehta MA. Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge. Neuroimage. October 2010;52(4):1521-1527.

Publication Date
October 2010

How Analyze was Used
“The ROIs were spatially normalised from standard space to individual space by applying the deformation matrix previously generated by the normalisation of individual add images to a [11C]-raclopride template using SPM5 and were converted into object maps using Analyze 8.0 software (www.analyzedirect.com).”

Keywords
Adult
Dopamine/metabolism
Dronabinol/administration & dosage
Female
Frontal Lobe/drug effects/metabolism/radionuclide imaging
Humans
Male
Psychotropic Drugs/administration & dosage
Raclopride/diagnostic use/pharmacokinetics
Radiopharmaceuticals/diagnostic use/pharmacokinetics
Receptors, Dopamine D2/antagonists & inhibitors
Temporal Lobe/drug effects/metabolism/radionuclide imaging
Tissue Distribution/drug effects

Author Affiliation(s)
Psychiatry Group, MRC Clinical Science Centre, Imperial College, Hammersmith Hospital, London, UK. (PRAS, AE, MAM)

Psychosis Clinical Academic Group, P067, Department of Psychological Medicine and Psychiatry, Institute of Psychiatry, King’s College London, London, UK. (AE)

Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, King’s College London, London, UK. (MAM)

MRC Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry at King’s College London, London, UK. (GB)

Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, Imperial College, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK. (PRAS, BW, AR, AL-H, DJN)

ID# 1083

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