AnalyzeDirect

Merchant M, Evangelista M, Luoh SM, Frantz GD, Chalasani S, Carano RAD, van Hoy M, Ramirez J, Ogasawara AK, McFarland LM, Filvaroff EH, French DM, de Sauvage FJ. Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus. Mol Cell Biol. August 2005;25(16):7054-7068.

Full Text – Open Access

Publication Date
August 2005

How Analyze was Used
“Three-dimensional surface renderings were created from the μCT data using the Analyze software package (AnalyzeDirect Inc., Lenexa, KS). Applying a bone mineral density threshold of 0.45 g of hydroxyapatite/cm3 generated bone surface renderings.”

Keywords
Animals
Axin Protein
Cell Lineage
Cell Proliferation
Cerebrospinal Fluid/metabolism
Dose-Response Relationship, Drug
Gene Expression Regulation, Developmental
Genes, Reporter
Genotype
Heterozygote
Hydrocephalus/etiology/genetics/metabolism
In Situ Hybridization
Magnetic Resonance Imaging (MRI)
Mice
Mice, Inbred C57BL
Mice, Knockout
Microscopy, Fluorescence
Models, Genetic
Protein-Serine-Threonine Kinases/metabolism
RNA, Small Interfering/metabolism
Repressor Proteins/genetics/physiology
Reverse Transcriptase Polymerase Chain Reaction
Rhinitis/genetics
Signal Transduction
Time Factors
Tissue Distribution
Transcription, Genetic
beta-Galactosidase/metabolism

Author Affiliation(s)
Department of Molecular Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, US. (MM, ME, FJdS)

Department of Bioinformatics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, US. (SML)

Department of Pathology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, US. (GDF, SC, MvH, JR, DMF)

Department of Biomedical Imaging, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, US. (RADC, AKO, LMF)

Department of Molecular Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, US. (EHF)

ID# 2138

Tags: Animals, Axin Protein, beta-Galactosidase/metabolism, Cell Lineage, Cell Proliferation, Cerebrospinal Fluid/metabolism, Developmental Gene Expression Regulation, Drug Dose-Response Relationship, Fluorescence Microscopy, Genetic Models, Genetic Transcription, Genotype, Heterozygote, Hydrocephalus/etiology/genetics/metabolism, In Situ Hybridization, Inbred C57BL Mice, Knockout Mice, Magnetic Resonance Imaging (MRI), Mice, Protein-Serine-Threonine Kinases/metabolism, Reporter Genes, Repressor Proteins/genetics/physiology, Reverse Transcriptase Polymerase Chain Reaction, Rhinitis/genetics, Signal Transduction, Small Interfering RNA/metabolism, Time Factors, Tissue Distribution