Analyze Publications Database

In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model

Nanditha Mohan Das1, Sarah Hatsell1, Kalyan Nannuru1, Lily Huang1, Xialing Wen1, Lili Wang1, Li-Hsien Wang1, Vincent Idone1, Jeffrey A. Meganck2, Andrew Murphy1, Aris Economides1, and LiQin Xie1. In Vivo Quantitative Microcomputed Tomographic Analysis of Vasculature and Organs in a Normal and Diseased Mouse Model. PLoS One. February 24th, 2016.

Full Text – Open Access

 

Publication Date
February 2016

How Analyze was Used
“Following scanning, image processing steps were undertaken. Image segmentation was performed semi-automatically using the Volume Edit tools within the Analyze software package (AnalyzeDirect, Overland Park, KS, USA). Briefly, segmentation masks(object maps) were created using a combination of semi-automatic and manual techniques (object extraction, region growing and thresholding tools). These segmentation results were then manually modified if necessary and quantified using the ROI tools.”

Additionally, segmentation and volume calculation of vessels and organs (heart, liver, kidney and spleen), visualization of vessels around the head and hind limbs, disease monitoring of tumor related angiogenesis and bone degeneration around the knee joint,  and disease monitoring via changes in organ volume and organ morphology were all performed using Analyze in this study.

Author Affiliation(s)
1 Department of Skeletal Diseases – Therapeutic Focus Areas, Regeneron Pharmaceuticals Inc., Tarrytown, New York, United States of America
2 Research and Development, PerkinElmer, Hopkinton, Massachusetts, United States of America

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