AnalyzeDirect

Lin X, Tench CR, Turner B, Blumhardt LD, Constantinescu CS. Spinal cord atrophy and disability in multiple sclerosis over four years: application of a reproducible automated technique in monitoring disease progression in a cohort of the interferon beta-1a (Rebif) treatment trial. J Neurol Neurosurg Psychiatry. August 2003;74(8):1090-1094.

Full Text – Open Access

Publication Date
August 2003

How Analyze was Used
“T2 lesion volume was determined by outlining observer identified lesions on T2 weighted images using a semiautomated technique on ANALYZE.”

Keywords
Adult
Atrophy
Cohort Studies
Disability Evaluation
Disease Progression
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Image Enhancement/methods
Image Processing, Computer-Assisted/methods
Imaging, Three-Dimensional
Injections, Subcutaneous
Interferon-beta/administration & dosage
Magnetic Resonance Imaging (MRI)/methods
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive/diagnosis/drug therapy
Multiple Sclerosis, Relapsing-Remitting/diagnosis/drug therapy
Observer Variation
Spinal Cord/pathology

Author Affiliation(s)
Division of Clinical Neurology, Faculty of Medicine, Queen’s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.

ID# 2402

Tags: Adult, Atrophy, Chronic Progressive Multiple Sclerosis/diagnosis/drug therapy, Cohort Studies, Computer-Assisted Image Processing/methods, Disability Evaluation, Disease Progression, Drug Dose-Response Relationship, Female, Follow-Up Studies, Humans, Image Enhancement/methods, Interferon-beta/administration & dosage, Magnetic Resonance Imaging (MRI)/methods, Male, Middle Aged, Observer Variation, Relapsing-Remitting Multiple Sclerosis/diagnosis/drug therapy, Spinal Cord/pathology, Subcutaneous Injections, Three-Dimensional Imaging