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Yang J, Kalogerou M, Gallacher J, Sampson JR, Shen MH. Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin. Eur J Cancer. April 2013;49(6):1479-1490.

Publication Date
April 2013

How Analyze was Used
“The volumes of renal lesions were measured using the software Analyze 9.0 (AnalyzeDirect, Inc., Overland Park, United States of America).”

Keywords
Animals
Azacitidine/analogs & derivatives/pharmacology
Blotting, Western
Catecholamine Plasma Membrane Transport Proteins/genetics/metabolism
Disease Models, Animal
Epigenesis, Genetic
Gene Expression Regulation, Neoplastic/drug effects
Histone Deacetylases/metabolism
Hypoglycemic Agents/pharmacology
Immunohistochemistry
Kidney/drug effects/metabolism/pathology
Kidney Neoplasms/drug therapy/genetics/metabolism
Metformin/pharmacology
Mice
Mice, Knockout
Multiprotein Complexes/metabolism
Organic Cation Transport Proteins/genetics/metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction/drug effects
TOR Serine-Threonine Kinases/metabolism
Tuberous Sclerosis/drug therapy/genetics/metabolism
Tumor Cells, Cultured
Tumor Suppressor Proteins/deficiency/genetics

Author Affiliation(s)
Institute of Medical Genetics, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. (JY, MK, JRS, MHS)

Department of Primary Care & Public Health, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4YS, UK. (JG)

ID# 212

Tags: Animal Disease Models, Animals, Azacitidine/analogs & derivatives/pharmacology, Catecholamine Plasma Membrane Transport Proteins/genetics/metabolism, Cultured Tumor Cells, Gene Expression Regulation, Genetic Epigenesis, Histone Deacetylases/metabolism, Hypoglycemic Agents/pharmacology, Immunohistochemistry, Kidney Neoplasms/drug therapy/genetics/metabolism, Kidney/drug effects/metabolism/pathology, Knockout Mice, Metformin/pharmacology, Mice, Multiprotein Complexes/metabolism, Neoplastic/drug effects, Organic Cation Transport Proteins/genetics/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction/drug effects, TOR Serine-Threonine Kinases/metabolism, Tuberous Sclerosis/drug therapy/genetics/metabolism, Tumor Suppressor Proteins/deficiency/genetics, Western Blotting