AnalyzeDirect Boska MD, Hasan KM, Kibuule D, Banerjee R, McIntyre E, Nelson JA, Hahn T, Gendelman HE, Mosley RL. Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease. Neurobiol Dis. June 2007;26(3):590-596.
Full Text – Open Access
Publication Date
June 2007
How Analyze was Used
“3D MRI scans were zero-filled to 256×256×64, input into Analyze … and the skulls were digitally removed from the brain tissue (subimaged).”
Keywords
Animals
Anisotropy
Brain Mapping/methods
Cell Count
Corpus Striatum/metabolism/pathology/physiopathology
Diffusion
Diffusion Magnetic Resonance Imaging/methods
Disease Models, Animal
Dopamine/metabolism
Male
Mice
Mice, Inbred C57BL
Nerve Degeneration/diagnosis/pathology/physiopathology
Nerve Fibers, Myelinated/metabolism/pathology
Neural Pathways/metabolism/pathology/physiopathology
Neurons/metabolism/pathology
Parkinsonian Disorders/diagnosis/pathology/physiopathology
Substantia Nigra/metabolism/pathology/physiopathology
Author Affiliation(s)
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198-1045, US. (MDB, DK, RB, EM, JAN, TH, HEG, RLM)
Department of Radiology, University of Nebraska Medical Center, Omaha, NE 68198-1045, US. (MDB, DK, EM, JAN)
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198-1045, US. (RB, TH, HEG, RLM)
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1045, US. (HEG)
Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston, Houston, TX 77030, US. (KMH)
ID# 1735
Tags: Animal Disease Models, Animals, Anisotropy, Brain Mapping/methods, Cell Count, Corpus Striatum/metabolism/pathology/physiopathology, Diffusion, Diffusion Magnetic Resonance Imaging/methods, Dopamine/metabolism, Inbred C57BL Mice, Male, Mice, Myelinated Nerve Fibers/metabolism/pathology, Nerve Degeneration/diagnosis/pathology/physiopathology, Neural Pathways/metabolism/pathology/physiopathology, Neurons/metabolism/pathology, Parkinsonian Disorders/diagnosis/pathology/physiopathology, Substantia Nigra/metabolism/pathology/physiopathology