AnalyzeDirect Zhu XY, Daghini E, Chade AR, Versari D, Krier JD, Textor KB, Lerman A, Lerman LO. Myocardial microvascular function during acute coronary artery stenosis: effect of hypertension and hypercholesterolaemia. Cardiovasc Res. July 2009;83(2):371-380.
Full Text – Open Access
Publication Date
July 2009
How Analyze was Used
“All EBCT images were reconstructed using a filtered back-projection algorithm, and then transferred for analysis on a Sun® workstation. End-diastolic images were analysed by manually tracing regions of interest in the LV [left ventricle] chamber and in the territories of the LAD [left anterior descending] and left circumflex (LCX, Figure 1) arteries (Analyze™ …). The change in the average CT number (Hounsfield units) in each region was then plotted as a time-attenuation curve that was fitted by an extended γ-variate model [Rodriguez-Porcel et al. 2001]. The area and first moment of each curve were then used for calculation of intra-myocardial blood volume and mean transit time, and myocardial perfusion (mL/min/g) was then calculated as previously shown [Rodriguez-Porcel et al. 2006, 2004; Zhu et al. 2004m 2006]. Myocardial vascular permeability (MVP, arbitrary units) was calculated from the slope of a curve representing extravascular leakage, as we have shown before [Rodriguez-Porcel et al., 2004].”
Keywords
Adenosine/administration & dosage
Animals
Capillary Permeability
Collateral Circulation
Coronary Angiography
Coronary Circulation
Coronary Stenosis/complications/physiopathology/radiography
Coronary Vessels/pathology/physiopathology
Disease Models, Animal
Female
Hypercholesterolemia/complications/physiopathology/radiography
Hypertension, Renovascular/complications/physiopathology/radiography
Infusions, Intravenous
Microcirculation
Neovascularization, Physiologic
Sus scrofa
Tomography, X-Ray Computed
X-Ray Microtomography
Author Affiliation(s)
Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, US. (X-YZ, ED, ARC, JDK, KBT, LOL)
Division of Cardiovascular diseases, Department of Internal Medicine, Mayo Clinic, Rochester, MN, US. (DV, AL, LOL)
ID# 1337
Tags: Adenosine/administration & dosage, Animal Disease Models, Animals, Capillary Permeability, Collateral Circulation, Coronary Angiography, Coronary Circulation, Coronary Stenosis/complications/physiopathology/radiography, Coronary Vessels/pathology/physiopathology, Female, Hypercholesterolemia/complications/physiopathology/radiography, Intravenous Infusions, Microcirculation, Physiologic Neovascularization, Renovascular Hypertension/complications/physiopathology/radiography, Sus scrofa, X-Ray Computed Tomography, X-Ray Microtomography