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Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy

Bhattacharya A, Tóth K, Mazurchuk R, Spernyak JA, Slocum HK, Pendyala L, Azrak R, Cao S, Durrani FA, Rustum YM. Lack of microvessels in well-differentiated regions of human head and neck squamous cell carcinoma A253 associated with functional magnetic resonance imaging detectable hypoxia, limited drug delivery, and resistance to irinotecan therapy. Clin Cancer Res. December 2004;10(23):8005-8017.

Full Text – Open Access

Publication Date
December 2004

How Analyze was Used
“We then analyzed the resultant images by commercial image analysis and visualization software (AnalyzePC Version 5 …) for grain counting using the object counter module.”

Keywords
Animals
Anoxia
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Camptothecin/administration & dosage/analogs & derivatives
Carcinoma, Squamous Cell/blood supply/drug therapy/radiotherapy
Cell Differentiation
Drug Delivery Systems
Drug Resistance, Neoplasm
Female
Fluorouracil/administration & dosage
Head and Neck Neoplasms/blood supply/drug therapy/radiotherapy
Humans
Magnetic Resonance Imaging (MRI)
Mice
Mice, Nude
Microcirculation
Oxygen/blood
Rats
Transplantation, Heterologous
Tumor Cells, Cultured
Tumor Markers, Biological/metabolism

Author Affiliation(s)
Department of Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY, US. (AB, RM, JAS, YMR)

Department of Pharmacology & Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, US. (KT, HKS, RA, SC, FAD)

Department of Medicine, Roswell Park Cancer Institute, Buffalo, NY, US. (LP)

ID# 2224

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