AnalyzeDirect Masyuk TV, Radtke BN, Stroope AJ, Banales JM, Masyuk AI, Gradilone SA, Gajdos GB, Chandok N, Bakeberg JL, Ward CJ, Ritman EL, Kiyokawa H, LaRusso NF. Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease. Gastroenterology. March 2012;142(3):622-633.e624.
Full Text – Open Access
Publication Date
March 2012
How Analyze was Used
“Quantitation was performed by Analyze…as described [Masyuk et al. 2004].”
Keywords
Animals
Bile Ducts, Intrahepatic/drug effects/enzymology/pathology
Cell Cycle/drug effects
Cell Proliferation/drug effects
Cells, Cultured
Cysts/drug therapy/enzymology/genetics/pathology
Disease Models, Animal
Enzyme Inhibitors/pharmacology
Humans
Kidney/drug effects/enzymology/pathology
Liver/drug effects/enzymology/pathology
Liver Diseases/drug therapy/enzymology/genetics/pathology
Mice
Mice, Knockout
Organ Size/drug effects
Polycystic Kidney, Autosomal Recessive/drug
therapy/enzymology/genetics/pathology
Rats
Receptors, Cell Surface/genetics/metabolism
TRPP Cation Channels/genetics/metabolism
Time Factors
Up-Regulation
Vitamin K 3/pharmacology
cdc25 Phosphatases/antagonists & inhibitors/deficiency/genetics/metabolism
Author Affiliation(s)
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, US. (TVM, BNR, AJS, JMB, AIM, SAG, GBG, NC, NFL)
Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, US. (JLB, CJW)
Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, US. (ELR)
Laboratory of Molecular Genetics, Division of Gene Therapy and Hepatology, University of Navarra School of Medicine, Clínica Universitaria, and CIMA, Ciberehd, Pamplona, Spain. (JMB)
Molecular Pharmacology & Biological Chemistry, Northwestern University, Chicago, IL, US. (HK)
ID# 602
Tags: Animal Disease Models, Animals, Autosomal Recessive Polycystic Kidney/drug therapy/enzymology/genetics/pathology, cdc25 Phosphatases/antagonists & inhibitors/deficiency/genetics/metabolism, Cell Cycle/drug effects, Cell Proliferation/drug effects, Cell Surface Receptors/genetics/metabolism, Cultured Cells, Cysts/drug therapy/enzymology/genetics/pathology, Enzyme Inhibitors/pharmacology, Humans, Intrahepatic Bile Ducts/drug effects/enzymology/pathology, Kidney/drug effects/enzymology/pathology, Knockout Mice, Liver Diseases/drug therapy/enzymology/genetics/pathology, Liver/drug effects/enzymology/pathology, Mice, Organ Size/drug effects, Rats, Time Factors, TRPP Cation Channels/genetics/metabolism, Up-Regulation, Vitamin K 3/pharmacology