AnalyzeDirect Seshasayee D, Wang H, Lee WP, Gribling P, Ross J, Van Bruggen N, Carano R, Grewal IS. A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response. J Biol Chem. July 2004;279(29):30202-30209.
Full Text – Open Access
Publication Date
July 2004
How Analyze was Used
“A three-dimensional surface rendering was created from the μCT data with Analyze (AnalyzeDirect Inc., Lenexa, KS), an image analysis software package.”
Keywords
Animals
Apoptosis
Arthritis/chemically induced/radiography
Blotting, Western
Carrier Proteins/metabolism/physiology
Cell Division
Cell Separation
Cell Survival
Cells, Cultured
Chemokines/metabolism
Cytokines/metabolism
Dose-Response Relationship, Drug
Flow Cytometry
Glycoproteins/metabolism
Humans
Immunoglobulin G/metabolism
Inflammation
Ligands
Lipopolysaccharides/metabolism
MAP Kinase Signaling System
Macrophages/metabolism
Membrane Glycoproteins/metabolism/physiology
Mice
Mice, Inbred BALB C
Mitogen-Activated Protein Kinase 1/metabolism
Mitogen-Activated Protein Kinase 3
Mitogen-Activated Protein Kinases/metabolism
Monocytes/metabolism
NF-kappa B/metabolism
Osteoprotegerin
Proto-Oncogene Proteins c-bcl-2/metabolism
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
Receptors, Cytoplasmic and Nuclear/metabolism
Receptors, Tumor Necrosis Factor
Recombinant Fusion Proteins/metabolism
Time Factors
Tomography, X-Ray Computed
Up-Regulation
bcl-X Protein
p38 Mitogen-Activated Protein Kinases
Author Affiliation(s)
Department of Immunology, Genentech, Inc., South San Francisco, CA 94080, US. (DS, HW, WPL, PG, ISG)
Department ofPhysiology, Genentech, Inc., South San Francisco, CA 94080, US. (JR, NVB, RC)
ID# 2289
Tags: Animals, Apoptosis, Arthritis/chemically induced/radiography, bcl-X Protein, Carrier Proteins/metabolism/physiology, Cell Division, Cell Separation, Cell Survival, Chemokines/metabolism, Cultured Cells, Cytokines/metabolism, Cytoplasmic and Nuclear Receptors/metabolism, Drug Dose-Response Relationship, Flow Cytometry, Glycoproteins/metabolism, Humans, Immunoglobulin G/metabolism, Inbred BALB C Mice, Inflammation, Ligands, Lipopolysaccharides/metabolism, Macrophages/metabolism, MAP Kinase Signaling System, Membrane Glycoproteins/metabolism/physiology, Mice, Mitogen-Activated Protein Kinase 1/metabolism, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinases/metabolism, Monocytes/metabolism, NF-kappa B/metabolism, Osteoprotegerin, p38 Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-bcl-2/metabolism, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Recombinant Fusion Proteins/metabolism, Time Factors, Tumor Necrosis Factor Receptors, Up-Regulation, Western Blotting, X-Ray Computed Tomography