AnalyzeDirect

Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, Van Bruggen N, Carano RAD, Michaelis S, Griffey SM, Young SG. Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc Natl Acad Sci U S A. October 2002;99(20):13049-13054.

Full Text – Open Access

Publication Date
October 2002

How Analyze was Used
“The cortical bone volume and density were determined by application of an automated image segmentation algorithm and image analysis software libraries (AnalyzeDirect, Lenexa, KS).”

Keywords
Age Factors
Animals
Bacterial Proteins/metabolism
Bone and Bones/injuries/radiography
Cell Membrane/enzymology
Fibroblasts/metabolism
Lamin Type A/metabolism
Matrix Metalloproteinases/genetics/physiology
Membrane Proteins/genetics/physiology
Metalloendopeptidases/genetics/physiology
Mice
Mice, Inbred C57BL
Muscle Weakness/genetics
Muscles/pathology
Nuclear Proteins/metabolism
Phenotype
Protein Precursors/metabolism
Protein Structure, Tertiary
Time Factors
Tomography, X-Ray Computed

Author Affiliation(s)
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141-9100, US. (MOB, BG, CH, SGY)

Cardiovascular Research Institute, University of California, San Francisco, CA 94143, US. (MOB, SGY)

Genentech, Incorporated, South San Francisco, CA 94080, US. (JR, NvB, RADC)

Department of Cell Biology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, US. (WKS, SM)

Comparative Pathology Laboratory, University of California, Davis, CA 95616, US. (LVK, ERW, SMG)

Department of Radiology, University of California, San Francisco, CA 94143, US. (AM, MM, HG, YJ)

Department of Medicine, University of California, and the Medical Services, San Francisco General Hospital, San Francisco, CA 94110, US. (SGY)

ID# 2506

Tags: Age Factors, Animals, Bacterial Proteins/metabolism, Bone and Bones/injuries/radiography, Cell Membrane/enzymology, Fibroblasts/metabolism, Inbred C57BL Mice, Lamin Type A/metabolism, Matrix Metalloproteinases/genetics/physiology, Membrane Proteins/genetics/physiology, Metalloendopeptidases/genetics/physiology, Mice, Muscle Weakness/genetics, Muscles/pathology Nuclear Proteins/metabolism, Phenotype, Protein Precursors/metabolism, Tertiary Protein Structure, Time Factors, X-Ray Computed Tomography