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Tumor vascular response to photodynamic therapy and the antivascular agent 5,6-dimethylxanthenone-4-acetic acid: implications for combination therapy

Seshadri M, Spernyak JA, Mazurchuk R, Camacho SH, Oseroff AR, Cheney RT, Bellnier DA. Tumor vascular response to photodynamic therapy and the antivascular agent 5,6-dimethylxanthenone-4-acetic acid: implications for combination therapy. Clin Cancer Res. June 2005;11(11):4241-4250.

Full Text – Open Access

Publication Date
June 2005

How Analyze was Used
“Image analysis and three-dimensional renderings were done using commercially available software (AnalyzePC version 5.0).”

Keywords
Aminolevulinic Acid/administration & dosage
Animals
Antigens, CD31/analysis
Antineoplastic Agents/pharmacology/therapeutic use
Capillary Permeability/drug effects
Chlorophyll/administration & dosage/analogs & derivatives
Combined Modality Therapy
Dose-Response Relationship, Drug
Immunohistochemistry
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms, Experimental/blood supply/drug therapy/pathology
Neovascularization, Pathologic/metabolism/pathology
Photochemotherapy
Treatment Outcome
Xanthones/pharmacology/therapeutic use

Author Affiliation(s)
Department of Cell Stress Biology (Photodynamic Therapy Center), Roswell Park Cancer Institute, Buffalo, NY, US. (MS, SHC, DAB)

Department of Cancer Biology (Preclinical MR Imaging Resource), Roswell Park Cancer Institute, Buffalo, NY, US. (JAS, RM)

Department of Dermatology, Roswell Park Cancer Institute, Buffalo, NY, US. (ARO)

Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY, US. (RTC)

ID# 2049

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