AnalyzeDirect Kurenova E, Liao J, He DH, Hunt D, Yemma M, Bshara W, Seshadri M, Cance WG. The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. Oncotarget. October 2013;4(10):1632-1646.
Full Text – Open Access
Publication Date
October 2013
How Analyze was Used
“Image processing and analysis were carried out using commercially available software (AnalyzePC; AnalyzeDirect). A primary tumor volume (mm3) was calculated from manually traced regions-of-interest (ROI) on multislice T2-weighted images.”
Keywords
Animals
Apoptosis/drug effects
Carcinoma, Pancreatic Ductal/drug therapy/metabolism/pathology
Cell Growth Processes/drug effects
Cell Line, Tumor
Cell Survival/drug effects
Ethylenediamines/pharmacology
Female
Focal Adhesion Protein-Tyrosine Kinases/antagonists & inhibitors/metabolism
Humans
MAP Kinase Signaling System/drug effects
Mice
Mice, SCID
Pancreatic Neoplasms/drug therapy/metabolism/pathology
Phosphorylation
Prognosis
Vascular Endothelial Growth Factor Receptor-3/metabolism
Xenograft Model Antitumor Assays
Author Affiliation(s)
Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY, US. (EK, JL, MY, WGC)
Department of Pathology, Roswell Park Cancer Institute, Buffalo, NY, US. (WB)
Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY, US. (MS)
University of Florida, Gainesville, FL, US. (DHH, DH)
CureFAKtor Pharmaceuticals, Orchard Park, NY, US. (EK, WGC)
ID# 443
Tags: Animals, Apoptosis/drug effects, Cell Growth Processes/drug effects, Cell Survival/drug effects, Ethylenediamines/pharmacology, Female, Focal Adhesion Protein-Tyrosine Kinases/antagonists & inhibitors/metabolism, Humans, MAP Kinase Signaling System/drug effects, Mice, Pancreatic Ductal Carcinoma/drug therapy/metabolism/pathology, Pancreatic Neoplasms/drug therapy/metabolism/pathology, Phosphorylation, Prognosis, SCID Mice, Tumor Cell Line, Vascular Endothelial Growth Factor Receptor-3/metabolism, Xenograft Model Antitumor Assays