AnalyzeDirect Desnoyers LR, Pai R, Ferrando RE, Hötzel K, Le T, Ross J, Carano R, D’Souza A, Qing J, Mohtashemi I, Ashkenazi A, French DM. Targeting FGF19 inhibits tumor growth in colon cancer xenograft and FGF19 transgenic hepatocellular carcinoma models. Oncogene. January 2008;27(1):85-97.
Full Text – Open Access
Publication Date
January 2008
How Analyze was Used
“Volumetric image files were analysed using image analysis software from AnalyzeDirect (Lenexa, KS, USA).”
Keywords
Animals
Antibodies, Blocking/therapeutic use
Antibodies, Monoclonal/therapeutic use
Antineoplastic Agents/pharmacology
Carcinoma, Hepatocellular/drug therapy/genetics/immunology
Carcinoma, Squamous Cell/drug therapy/immunology/metabolism
Colonic Neoplasms/drug therapy/genetics/immunology
Fibroblast Growth Factors/antagonists &
inhibitors/biosynthesis/genetics/immunology
Gene Targeting/methods
HCT116 Cells
HT29 Cells
Humans
Liver Neoplasms, Experimental/drug therapy/immunology
Lung Neoplasms/drug therapy/genetics/immunology
Mice
Mice, Inbred BALB C
Mice, Nude
Mice, Transgenic
Neoplasm Transplantation
Receptor, Fibroblast Growth Factor, Type 4/biosynthesis/genetics/metabolism
Transplantation, Heterologous
Xenograft Model Antitumor Assays/methods
Author Affiliation(s)
Department of Molecular Oncology, Genentech Inc., South San Francisco, CA, US. (LRD, AD, JQ, AA)
Department of Pathology, Genentech Inc., South San Francisco, CA, US. (RP, REF, KH, DMF)
Department of Biomedical Imaging, Genentech Inc., South San Francisco, CA, US. (TL, JR, RC)
Department of Protein Chemistry, Genentech Inc., South San Francisco, CA, US. (IM)
ID# 1601
Tags: Animals, Antineoplastic Agents/pharmacology, Blocking Antibodies/therapeutic use, Colonic Neoplasms/drug therapy/genetics/immunology, Experimental Liver Neoplasms/drug therapy/immunology, Fibroblast Growth Factor Receptor_ Type 4/biosynthesis/genetics/metabolism, Fibroblast Growth Factors/antagonists & inhibitors/biosynthesis/genetics/immunology, Gene Targeting/methods, HCT116 Cells, Hepatocellular Carcinoma/drug therapy/genetics/immunology, Heterologous Transplantation, HT29 Cells, Humans, Inbred BALB C Mice, Lung Neoplasms/drug therapy/genetics/immunology, Mice, Monoclonal Antibodies/therapeutic use, Neoplasm Transplantation, Nude Mice, Squamous Cell Carcinoma/drug therapy/immunology/metabolism, Transgenic Mice, Xenograft Model Antitumor Assays/methods