Tag Archives: Xenograft Model Antitumor Assays

The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth

Kurenova E, Liao J, He DH, Hunt D, Yemma M, Bshara W, Seshadri M, Cance WG. The FAK scaffold inhibitor C4 disrupts FAK-VEGFR-3 signaling and inhibits pancreatic cancer growth. Oncotarget. October 2013;4(10):1632-1646. Full Text – Open Access Publication Date October 2013 How Analyze was Used “Image processing and analysis were carried out using commercially available…

Vascular priming enhances chemotherapeutic efficacy against head and neck cancer

Folaron M, Kalmuk J, Lockwood J, Frangou C, Vokes J, Turowski SG, Merzianu M, Rigual NR, Sullivan-Nasca M, Kuriakose MA, Hicks WL, Jr., Singh AK, Seshadri M. Vascular priming enhances chemotherapeutic efficacy against head and neck cancer. Oral Oncol. September 2013;49(9):893-902. Full Text – Open Access Publication Date September 2013 How Analyze was Used “All…

Anti-tumor activity of the IGF-1R kinase inhibitor PQIP in colon cancer

Chowdhury S, Dominguez I, Sharratt E, Spernyak J, Brattain MG, Ashwani R. Anti-tumor activity of the IGF-1R kinase inhibitor PQIP in colon cancer. Clin Exp Pharmacol. June 2013;S4(005). Full Text – Open Access Publication Date June 2013 How Analyze was Used “Tumor volumes were calculated by manually drawing regions of interest (ROI’s) over the tumors…

Photodynamic therapy augments the efficacy of oncolytic vaccinia virus against primary and metastatic tumours in mice

Gil M, Bieniasz M, Seshadri M, Fisher D, Ciesielski MJ, Chen Y, Pandey RK, Kozbor D. Photodynamic therapy augments the efficacy of oncolytic vaccinia virus against primary and metastatic tumours in mice. Br J Cancer. November 2011;105(10):1512-1521. Full Text – Open Access Publication Date November 2011 How Analyze was Used “Raw image sets were transferred…

Bevacizumab enhances the therapeutic efficacy of Irinotecan against human head and neck squamous cell carcinoma xenografts

Cao S, Durrani FA, Toth K, Rustum YM, Seshadri M. Bevacizumab enhances the therapeutic efficacy of Irinotecan against human head and neck squamous cell carcinoma xenografts. Oral Oncol. June 2011;47(6):459-466. Full Text – Open Access Publication Date June 2011 How Analyze was Used “All post processing and analysis were performed using Analyze™ (AnalyzeDirect, Overland Park,…

Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer

Bhattacharya A, Turowski SG, San Martin ID, Rajput A, Rustum YM, Hoffman RM, Seshadri M. Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an orthotopic model of human colon cancer. Anticancer Res. February 2011;31(2):387-393. Full Text – Open Access Publication Date February 2011 How Analyze was Used “Image processing…

Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging

O’Connor JPB, Carano RAD, Clamp AR, Ross J, Ho CCK, Jackson A, Parker GJM, Rose CJ, Peale FV, Friesenhahn M, Mitchell CL, Watson Y, Roberts C, Hope L, Cheung S, Reslan HB, Go MAT, Pacheco GJ, Wu X, Cao TC, Ross S, Buonaccorsi GA, Davies K, Hasan J, Thornton P, del Puerto O, Ferrara N,…

Cooperation of the agonistic DR5 antibody apomab with chemotherapy to inhibit orthotopic lung tumor growth and improve survival

Jin H, Yang R, Ross J, Fong S, Carano R, Totpal K, Lawrence D, Zheng Z, Koeppen H, Stern H, Schwall R, Ashkenazi A. Cooperation of the agonistic DR5 antibody apomab with chemotherapy to inhibit orthotopic lung tumor growth and improve survival. Clin Cancer Res. December 2008;14(23):7733-7740. Full Text – Open Access Publication Date December…

Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs

Bhattacharya A, Seshadri M, Oven SD, Tόth K, Vaughan MM, Rustum YM. Tumor vascular maturation and improved drug delivery induced by methylselenocysteine leads to therapeutic synergy with anticancer drugs. Clin Cancer Res. June 2008;14(12):3926-3932. Full Text – Open Access Publication Date June 2008 How Analyze was Used “For determination of vessel lumen area, photomicrographs of…

Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy

Dinca EB, Sarkaria JN, Schroeder MA, Carlson BL, Voicu R, Gupta N, Berger MS, James CD. Bioluminescence monitoring of intracranial glioblastoma xenograft: response to primary and salvage temozolomide therapy. J Neurosurg. September 2007;107(3):610-616. Publication Date September 2007 How Analyze was Used “The images for each mouse were organized in spatial registration as a volume wrapper…