AnalyzeDirect

O’Connor JPB, Carano RAD, Clamp AR, Ross J, Ho CCK, Jackson A, Parker GJM, Rose CJ, Peale FV, Friesenhahn M, Mitchell CL, Watson Y, Roberts C, Hope L, Cheung S, Reslan HB, Go MAT, Pacheco GJ, Wu X, Cao TC, Ross S, Buonaccorsi GA, Davies K, Hasan J, Thornton P, del Puerto O, Ferrara N, van Bruggen N, Jayson GC. Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging. Clin Cancer Res. November 2009;15(21):6674-6682.

Full Text – Open Access

Publication Date
November 2009

How Analyze was Used
“Computations were done by an in-house image analysis algorithm written in C++ and Python that used the AVW image processing software library (AnalyzeDirect, Inc.). Three-dimensional surface renderings were created from the micro-CT data with the use of Analyze 7.0 (AnalyzeDirect, Inc.).”

Keywords
Adolescent
Angiogenesis Inhibitors/therapeutic use
Animals
Antibodies, Monoclonal/pharmacology/therapeutic use
Antibodies, Monoclonal, Humanized
Cell Line, Tumor
Colorectal Neoplasms/blood supply/drug therapy
Diagnostic Imaging
Drug Delivery Systems
Female
Humans
Mice
Mice, Nude
Neovascularization, Pathologic/drug therapy
Vascular Endothelial Growth Factor A/immunology
Xenograft Model Antitumor Assays

Author Affiliation(s)
Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester, Manchester, UK. (JPBO, AJ, GJMP, CJR, CLM, YW, CR, SC, GAB, KD)

Cancer Research UK and University of Manchester Department of Medical Oncology, Christie Hospital, Manchester, UK. (JPBO, ARC, CLM, LH, JH, PT, GCJ)

Biomedical Imaging Group, Department of Tumor Biology and Angiogenesis, Genentech, Inc., South San Francisco, California. (RADC, JR, CCKH, HBR, TCC, NB)

Department of Pathology, Genentech, Inc., South San Francisco, California. (FVP)

Department of Biostatistics, Genentech, Inc., South San Francisco, California. (MF)

Department of Translational Oncology, Genentech, Inc., South San Francisco, California. (MATG, GJP, SR)

Ferrara Laboratory, Genentech, Inc., South San Francisco, California. (XW, NF)

Roche Products Limited, Hertfordshire, UK. (OP)

ID# 1205

Tags: Adolescent, Angiogenesis Inhibitors/therapeutic use, Animals, Colorectal Neoplasms/blood supply/drug therapy, Diagnostic Imaging, Drug Delivery Systems, Female, Humanized Monoclonal Antibodies, Humans, Mice, Monoclonal Antibodies/pharmacology/therapeutic use, Nude Mice, Pathologic Neovascularization/drug therapy, Tumor Cell Line, Vascular Endothelial Growth Factor A/immunology, Xenograft Model Antitumor Assays