Tag Archives: Brain/metabolism

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer’s disease

Trushina E, Nemutlu E, Zhang S, Christensen T, Camp J, Mesa J, Siddiqui A, Tamura Y, Sesaki H, Wengenack TM, Dzeja PP, Poduslo JF. Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial Alzheimer’s disease. PLoS One. February 2012;7(2):e32737. Full Text – Open Access Publication Date February 2012…

Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. Validation using [14C]2-deoxyglucose autoradiography

Robertson CA, McCabe C, Gallagher L, Lopez-Gonzalez Mdel R, Holmes WM, Condon B, Muir KW, Santosh C, Macrae IM. Stroke penumbra defined by an MRI-based oxygen challenge technique: 1. Validation using [14C]2-deoxyglucose autoradiography. J Cereb Blood Flow Metab. August 2011;31(8):1778-1787. Full Text – Open Access Publication Date August 2011 How Analyze was Used “Linear coregistration…

Reliability of two techniques for assessing cerebral iron deposits with structural magnetic resonance imaging

Valdés Hernández MC, Jeong TH, Murray C, Bastin ME, Chappell FM, Deary IJ, Wardlaw JM. Reliability of two techniques for assessing cerebral iron deposits with structural magnetic resonance imaging. J Magn Reson Imaging. January 2011;33(1):54-61. Publication Date January 2011 How Analyze was Used “A brain mask was then obtained from the T2*W data using the…

Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study

Governo RJM, Morris PG, Marsden CA, Chapman V. Gabapentin evoked changes in functional activity in nociceptive regions in the brain of the anaesthetized rat: an fMRI study. Br J Pharmacol. April 2008;153(7):1558-1567. Full Text – Open Access Publication Date April 2008 How Analyze was Used “All volume data acquired from each study were motion corrected…

How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET

Takasawa M, Jones PS, Guadagno JV, Christensen S, Fryer TD, Harding S, Gillard JH, Williams GB, Aigbirhio FI, Warburton EA, Østergaard L, Baron JC. How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET. Stroke. March 2008;39(3):870-877. Full Text – Open Access Publication Date March 2008 How…

Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study

Edison P, Archer HA, Hinz R, Hammers A, Pavese N, Tai YF, Hotton G, Cutler D, Fox N, Kennedy A, Rossor M, Brooks DJ. Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study. Neurology. February 2007;68(7):501-508. Publication Date February 2007 How Analyze was Used “Mean cerebellar tracer uptake was then calculated…

Longitudinal changes during aging using proton magnetic resonance spectroscopy

Ross AJ, Sachdev PS, Wen W, Brodaty H. Longitudinal changes during aging using proton magnetic resonance spectroscopy. J Gerontol A Biol Sci Med Sci. March 2006;61(3):291-298. Full Text – Open Access Publication Date March 2006 How Analyze was Used “To correct for partial volume effects within the voxels, the proportion of cerebrospinal fluid (CSF) was…

Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury

Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK. Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury. Brain. August 2005;128(Pt 8):1931-1942. Full Text – Open Access Publication Date August…

Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla

Jensen JE, Miller J, Williamson PC, Neufeld RWJ, Menon RS, Malla A, Manchanda R, Schaefer B, Densmore M, Drost DJ. Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla. Br J Psychiatry. May 2004;184:409-415. Full Text – Open Access Publication Date May 2004 How Analyze…

Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-ϵ4 allele

Cohen RM, Podruchny TA, Bokde ALW, Carson RE, Herscovitch P, Kiesewetter DO, Eckelman WC, Sunderland T. Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-ϵ4 allele. Synapse. September 2003;49(3):150-156. Publication Date September 2003 How Analyze was Used “Each acquired PET volume was corrected for partial voluming (PVC) on a Silicon…