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Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering

Bonetti PO, Wilson SH, Rodriguez-Porcel M, Holmes DR, Jr., Lerman LO, Lerman A. Simvastatin preserves myocardial perfusion and coronary microvascular permeability in experimental hypercholesterolemia independent of lipid lowering. J Am Coll Cardiol. August 2002;40(3):546-554.

Full Text – Open Access

Publication Date
August 2002

How Analyze was Used
“EBCT images were transferred to a Sun workstation and regions of interest were traced in the anterior wall and chamber of the left ventricle using the image analysis software package Analyze …, and time-density curves were generated for both regions.”

Keywords
Animals
Anticholesteremic Agents/pharmacokinetics/therapeutic use
Body Weight/physiology
Capillary Permeability/drug effects
Cholesterol, HDL/blood
Cholesterol, LDL/blood
Coronary Vessels/drug effects/physiology/ultrasonography
Disease Models, Animal
Female
Hemodynamics/physiology
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacokinetics/therapeutic use
Hypercholesterolemia/drug therapy/ultrasonography
Models, Cardiovascular
Myocardial Ischemia/drug therapy/prevention & control
Random Allocation
Simvastatin/pharmacokinetics/therapeutic use
Stroke Volume/physiology
Swine
Tomography, X-Ray Computed
Treatment Outcome

Author Affiliation(s)
Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, US. (POB, SHW, MRP, DRH, AL)

Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, US. (LOL)

ID# 2536

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