AnalyzeDirect Chung I, Han G, Seshadri M, Gillard BM, Yu WD, Foster BA, Trump DL, Johnson CS. Role of vitamin D receptor in the antiproliferative effects of calcitriol in tumor-derived endothelial cells and tumor angiogenesis in vivo. Cancer Res. February 2009;69(3):967-975.
Full Text – Open Access
Publication Date
February 2009
How Analyze was Used
“Vessel lumen area was determined using the software Analyze 7.0 (AnalyzeDirect), by measuring the vessel lumen circumference stained with CD31 antibody.”
Keywords
Adenocarcinoma/blood supply/drug therapy/pathology
Angiopoietin-1/biosynthesis
Animals
Calcitriol/pharmacology
Endothelial Cells/drug effects/metabolism/pathology
Hypoxia-Inducible Factor 1, alpha Subunit/biosynthesis
Male
Mice
Mice, Knockout
Neovascularization, Pathologic/drug therapy/metabolism/pathology
Prostatic Neoplasms/blood supply/drug therapy/pathology
Proto-Oncogene Proteins c-sis/biosynthesis
Receptors, Calcitriol/biosynthesis/deficiency/genetics/metabolism
Vascular Endothelial Growth Factor A/biosynthesis
Author Affiliation(s)
Departments of 1Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, NY. (IV, GH, BMG, WdY, BAF, CSJ)
Cancer Biology, Roswell Park Cancer Institute, Buffalo, NY. (MS)
Medicine, Roswell Park Cancer Institute, Buffalo, NY. (DLT)
ID# 1206
Tags: Adenocarcinoma/blood supply/drug therapy/pathology, Angiopoietin-1/biosynthesis, Animals, Calcitriol Receptors/biosynthesis/deficiency/genetics/metabolism, Calcitriol/pharmacology, Endothelial Cells/drug effects/metabolism/pathology, Hypoxia-Inducible Factor 1_alpha Subunit/biosynthesis, Knockout Mice, Male, Mice, Pathologic Neovascularization/drug therapy/metabolism/pathology, Prostatic Neoplasms/blood supply/drug therapy/pathology, Proto-Oncogene Proteins c-sis/biosynthesis, Vascular Endothelial Growth Factor A/biosynthesis