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Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering

Kempen DHR, Lu L, Hefferan TE, Creemers LB, Maran A, Classic KL, Dhert WJA, Yaszemski MJ. Retention of in vitro and in vivo BMP-2 bioactivities in sustained delivery vehicles for bone tissue engineering. Biomaterials. August 2008;29(22):3245-3252.

Full Text – Open Access

Publication Date
August 2008

How Analyze was Used
“Image analysis was performed using the Analyze software package… The volume of the subcutaneously formed bone was quantified in µCT reconstructions of the calcified tissue.”

Keywords
Animals
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins/administration & dosage/pharmacokinetics/pharmacology
Bone and Bones/cytology/drug effects
Cell Line
Fumarates/chemistry
Gelatin/chemistry
Hydrogels/chemistry
Lactic Acid/chemistry
Male
Mice
Microspheres
Osteogenesis/drug effects
Polyglycolic Acid/chemistry
Polypropylenes/chemistry
Rats
Rats, Sprague-Dawley
Tissue Engineering/methods
Transforming Growth Factor beta/administration & dosage/pharmacokinetics/pharmacology

Author Affiliation(s)
Tissue Engineering and Biomaterials Laboratory, Department of Orthopedic Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, US. (DHRK, LL, TEH, AM, MJY)

Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, US. (DHRK, LL, MJY)

Department of Orthopaedics, University Medical Center, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands. (DHRK, LBC, WJAD)

Radiation Safety, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, US. (KLC)

ID# 1578

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