AnalyzeDirect

Shoghi KI, Xu J, Su Y, He J, Rowland D, Yan Y, Garbow JR, Tu Z, Jones LA, Higashikubo R, Wheeler KT, Lubet RA, Mach RH, You M. Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(¹⁸)F]ISO-1. PLoS One. September 2013;8(9):e74188.

Full Text – Open Access

Publication Date
September 2013

How Analyze was Used
“Volumes of interest (VOIs) masks were drawn on PET images using the program Analyze.”

Keywords
Alkylating Agents/toxicity
Animals
Anticarcinogenic Agents/therapeutic use
Apoptosis/drug effects
Benzamides/diagnostic use
Blotting, Western
Cell Proliferation/drug effects
Female
Flow Cytometry
Fluorodeoxyglucose F18/diagnostic use
Humans
Image Processing, Computer-Assisted
Ligands
Mammary Neoplasms, Animal/chemically induced/drug therapy/metabolism/radionuclide imaging
Methylnitrosourea/toxicity
Mice
Positron-Emission Tomography (PET)
Radiopharmaceuticals/diagnostic use
Rats
Receptors, sigma/metabolism
Tetrahydronaphthalenes/therapeutic use
Triazoles/therapeutic use
Tumor Cells, Cultured

Author Affiliation(s)
Department of Radiology, Washington University School of Medicine, St. Louis, MO, US. (KIS, JX, YS, JRG, ZT, LAJ, RHM)

Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, US. (KIS)

Department of Surgery, Washington University School of Medicine, St. Louis, MO, US. (JH, YY, RH, MY)

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, US. (RHM)

Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, US. (RHM)

Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, MO, US. (KIS, RHM)

Center for Molecular and Genomic Imaging, University of California Davis, Davis, CA, US. (DR)

Department of Radiology, Wake Forest University Health Science Center, Winston-Salem, NC, US. (KTW)

National Institutes of Health, Bethesda, MD, US. (RAL)

Cancer Center and Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, US. (MY)

ID# 437

Tags: Alkylating Agents/toxicity, Animal Mammary Neoplasms/chemically induced/drug therapy/metabolism/radionuclide imaging, Animals, Anticarcinogenic Agents/therapeutic use, Apoptosis/drug effects, Benzamides/diagnostic use, Cell Proliferation/drug effects, Computer-Assisted Image Processing, Cultured Tumor Cells, Female, Flow Cytometry, Fluorodeoxyglucose F18/diagnostic use, Humans, Ligands, Methylnitrosourea/toxicity, Mice, Positron Emission Tomography (PET), Radiopharmaceuticals/diagnostic use, Rats, sigma Receptors/metabolism, Tetrahydronaphthalenes/therapeutic use, Triazoles/therapeutic use, Western Blotting