AnalyzeDirect Leow CC, Wang BE, Ross J, Chan SM, Zha J, Carano RAD, Frantz G, Shen MM, de Sauvage FJ, Gao WQ. Prostate-specific Klf6 inactivation impairs anterior prostate branching morphogenesis through increased activation of the Shh pathway. J Biol Chem. July 2009;284(31):21057-21065.
Full Text – Open Access
Publication Date
July 2009
How Analyze was Used
“Micro-CT was used to provide a quantitative analysis of the number of ductal tips and branch points….Acquired images were then analyzed using image analysis software from AnalyzeDirect (Lenexa, KS).”
Keywords
Animals
Bone Morphogenetic Protein 4/metabolism
Gene Deletion
Gene Expression Regulation, Developmental
Gene Silencing
Hedgehog Proteins/metabolism
Kruppel-Like Transcription Factors/deficiency/genetics/metabolism
Male
Mice
Morphogenesis
Muscle, Smooth/growth & development
Organ Specificity
Prostate/abnormalities/growth & development/metabolism/pathology
Proto-Oncogene Proteins/deficiency/genetics/metabolism
Signal Transduction
Up-Regulation/genetics
beta-Galactosidase/metabolism
Author Affiliation(s)
Department of Molecular Biology, Genentech Inc., South San Francisco, California 94080. (CCL, B-eW, FJS, W-QG)
Department of Tumor Biology and Angiogenesis, Genentech Inc., South San Francisco, California 94080. (JR, RADC)
Department of Pathology, Genentech Inc., South San Francisco, California 94080. (SMC, JZ, GF)
Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032. (MMS)
ID# 1276
Tags: Animals, beta-Galactosidase/metabolism, Bone Morphogenetic Protein 4/metabolism, Developmental, Gene Deletion, Gene Expression Regulation, Gene Silencing, Hedgehog Proteins/metabolism, Kruppel-Like Transcription Factors/deficiency/genetics/metabolism, Male, Mice, Morphogenesis, Organ Specificity, Prostate/abnormalities/growth & development/metabolism/pathology, Proto-Oncogene Proteins/deficiency/genetics/metabolism, Signal Transduction, Smooth Muscle/growth & development, Up-Regulation/genetics