AnalyzeDirect Healy AM, Izmailova E, Fitzgerald M, Walker R, Hattersley M, Silva M, Siebert E, Terkelsen J, Picarella D, Pickard MD, LeClair B, Chandra S, Jaffee B. PKC-theta-deficient mice are protected from Th1-dependent antigen-induced arthritis. J Immunol. August 2006;177(3):1886-1893.
Full Text – Open Access
Publication Date
August 2006
How Analyze was Used
“Raw microCT data were imported into the software package Analyze ( … AnalyzeDirect). Background and soft tissue were segmented from the bone in the images using histogram analysis.”
Keywords
Animals
Antigens/administration & dosage/immunology
Arthritis, Experimental/enzymology/genetics/immunology/prevention & control
Autoantibodies/biosynthesis/blood
Cell Movement/genetics/immunology
Cell Proliferation
Collagen/administration & dosage/immunology
Down-Regulation/genetics/immunology
Female
Immunophenotyping
Isoenzymes/deficiency/genetics/physiology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Knockout
Protein Kinase C/deficiency/genetics/physiology
Serum Albumin, Bovine/administration & dosage/immunology
T-Box Domain Proteins
T-Lymphocytes/immunology/pathology
Th1 Cells/immunology/pathology
Transcription Factors/biosynthesis
Up-Regulation/immunology
Author Affiliation(s)
nflammation Department, Millennium Pharmaceuticals, Cambridge, MA 02139, US. (AMH, EI, MF, RW, MH, JT, DP, MDP, BL, BJ)
Imaging Sciences, Millennium Pharmaceuticals, Cambridge, MA 02139, US. (MS, ES, SC)
ID# 1847
Tags: Animals, Antigens/administration & dosage/immunology, Autoantibodies/biosynthesis/blood, Bovine Serum Albumin/administration & dosage/immunology, Cell Movement/genetics/immunology, Cell Proliferation, Collagen/administration & dosage/immunology, Down-Regulation/genetics/immunology, Experimental Arthritis/enzymology/genetics/immunology/prevention & control, Female, Immunophenotyping, Inbred C57BL Mice, Inbred DBA Mice, Isoenzymes/deficiency/genetics/physiology, Knockout Mice, Male, Mice, Protein Kinase C/deficiency/genetics/physiology, T-Box Domain Proteins, T-Lymphocytes/immunology/pathology, Th1 Cells/immunology/pathology, Transcription Factors/biosynthesis, Up-Regulation/immunology