AnalyzeDirect Morris JB, Olzinski AR, Bernard RE, Aravindhan K, Mirabile RC, Boyce R, Willette RN, Jucker BM. p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment. Arterioscler Thromb Vasc Biol. February 2008;28(2):265-271.
Full Text – Open Access
Publication Date
February 2008
How Analyze was Used
“All images were analyzed using Analyze AVW software (AnalyzeDirect). Images were reconstructed to 512 pixels×512 pixels before semiautomated trace analysis.”
Keywords
Angiotensin II/administration & dosage
Animals
Aorta/pathology
Apolipoproteins E/genetics
Atherosclerosis/diagnosis
Contrast Media/pharmacokinetics
Enzyme Inhibitors/pharmacology
Feasibility Studies
Ferrosoferric Oxide/diagnostic use/pharmacokinetics
Imidazoles/pharmacology
Inflammation/diagnosis
Magnetic Resonance Angiography/methods
Male
Metal Nanoparticles/diagnostic use
Mice
Mice, Knockout
Pyrimidines/pharmacology
Vasoconstrictor Agents/administration & dosage
p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors
Author Affiliation(s)
Laboratory Animal Science, GlaxoSmithKline, King of Prussia, PA, US. (JBM)
Cardiovascular and Urogenital Center of Excellence in Drug Discovery, GlaxoSmithKline, King of Prussia, PA, US. (ARO, REB, KA, RNW, BMJ)
Safety Assessment, GlaxoSmithKline, King of Prussia, PA, US. (RCM, RB)
ID# 1474
Tags: Angiotensin II/administration & dosage, Animals, Aorta/pathology, Apolipoproteins E/genetics, Atherosclerosis/diagnosis, Contrast Media/pharmacokinetics, Enzyme Inhibitors/pharmacology, Feasibility Studies, Ferrosoferric Oxide/diagnostic use/pharmacokinetics, Imidazoles/pharmacology, Inflammation/diagnosis, Knockout Mice, Magnetic Resonance Angiography/methods, Male, Metal Nanoparticles/diagnostic use, Mice, p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors, Pyrimidines/pharmacology, Vasoconstrictor Agents/administration & dosage