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Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson’s disease

Hu MTM, Scherfler C, Khan NL, Hajnal JV, Lees AJ, Quinn N, Wood NW, Brooks DJ. Nigral degeneration and striatal dopaminergic dysfunction in idiopathic and Parkin-linked Parkinson’s disease. Mov Disord. March 2006;21(3):299-305.

Publication Date
March 2006

How Analyze was Used
“These nigral images, thresholded to similar maximum and minimum intensities (5 and 0, respectively), were then shown in color using Analyze 7.5 to an observer blinded to the individual subject group identification (DJB), who independently visually rated all images as normal.”

Keywords
Adult
Caudate Nucleus/metabolism/pathology
Corpus Striatum/metabolism/physiopathology
Dopamine/metabolism
Female
Fluorodeoxyglucose F18/diagnostic use/pharmacokinetics
Humans
Magnetic Resonance Imaging (MRI)
Male
Middle Aged
Nerve Degeneration/metabolism/pathology
Parkinson Disease/genetics/pathology/radionuclide imaging
Point Mutation/genetics
Positron-Emission Tomography (PET)
Putamen/metabolism/pathology
Radiopharmaceuticals/diagnostic use/pharmacokinetics
Substantia Nigra/metabolism/pathology
Ubiquitin-Protein Ligases/genetics

Author Affiliation(s)
MRC Clinical Sciences Centre, Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK. (MTMH, CS, DJB)

Robert Steiner MR Unit, Imperial College School of Medicine, Hammersmith Hospital, London, UK. (MTMH, JVH)

National Hospital for Neurology and Neurosurgery, London, UK. (MTMH, NLK, AJL, NQ, NWW, DJB)

Department of Molecular Pathogenesis, Institute of Neurology, London, UK. (NLK, NWW)

Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK. (AJL, NQ, DJB)

ID# 2000

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