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Li G, Zou L, Jack CR, Jr., Yang Y, Yang ES. Neuroprotective effect of Coenzyme Q10 on ischemic hemisphere in aged mice with mutations in the amyloid precursor protein. Neurobiol Aging. June 2007;28(6):877-882.

Publication Date
June 2007

How Analyze was Used
“The volume of each infarct was delineated with manual region of interest (ROI) tracing using image-processing software (Analyze 5.0; AnalyzeDirect, USA). For the calculation of hemispheric and hippocampal volumes, ROIs were manually drawn on two consecutive slices of the 3D-TSE T1-weighted images using Analyze. In order to correct for normal size differences between animals, volume results were expressed as a ratio relative to the unaffected hemisphere [Barrone et al., 1991, Hattori et al. 2000].”

Keywords
Aging
Amyloid beta-Protein Precursor/genetics
Analysis of Variance
Animals
Coenzymes
Functional Laterality
Hippocampus/drug effects/pathology
Humans
Ischemia/pathology/prevention & control
Magnetic Resonance Imaging (MRI)/methods
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mutation
Neuroprotective Agents/therapeutic use
Presenilin-1/genetics
Ubiquinone/analogs & derivatives/therapeutic use

Author Affiliation(s)
Jockey Club MRI Center, Faculty of Medicine, The University of Hong Kong, Room 204, Chow Yei Ching Bldg., Pokfulam Road, Hong Kong, China. (GL, ESY)

Department of Neurology, The First Affiliated Hospital, Harbin Medical University, PR China. (LZ)

Department of Diagnostic Radiology, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, US. (CRJ)

Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Building C, Baltimore, MD 21224, US. (YY)

ID# 1657

Tags: Aging, Amyloid beta-Protein Precursor/genetics, Analysis of Variance, Animals, Coenzymes, Functional Laterality, Hippocampus/drug effects/pathology, Humans, Inbred C57BL Mice, Ischemia/pathology/prevention & control, Magnetic Resonance Imaging (MRI)/methods, Male, Mice, Mutation, Neuroprotective Agents/therapeutic use, Presenilin-1/genetics, Transgenic Mice, Ubiquinone/analogs & derivatives/therapeutic use