AnalyzeDirect Collingridge DR, Glaser M, Osman S, Barthel H, Hutchinson OC, Luthra SK, Brady F, Bouchier-Hayes L, Martin SJ, Workman P, Price P, Aboagye EO. In vitro selectivity, in vivo biodistribution and tumour uptake of annexin V radiolabelled with a positron emitting radioisotope. Br J Cancer. October 2003;89(7):1327-1333.
Full Text – Open Access
Publication Date
October 2003
How Analyze was Used
“A single static frame from 30 to 60 min postinjection was obtained and visualised using the image analysis software, Analyze (version 4.0).”
Keywords
Animals
Annexin A5/pharmacokinetics
Antimetabolites, Antineoplastic/therapeutic use
Apoptosis
Deoxyadenosines/pharmacokinetics
Enzyme Inhibitors/pharmacokinetics
Fibrosarcoma/drug therapy/metabolism/pathology/radionuclide imaging
Flow Cytometry
Fluorouracil/therapeutic use
Humans
In Situ Nick-End Labeling
In Vitro Techniques
Iodine Radioisotopes/diagnostic use
Isotope Labeling/methods
Mice
Mice, Inbred C3H
Protein Binding
Sarcoma, Experimental/drug therapy/metabolism/pathology/radionuclide imaging
Thionucleosides/pharmacokinetics
Tissue Distribution
Tomography, Emission-Computed
Tumor Cells, Cultured
Author Affiliation(s)
Cancer Research UK PET Oncology Group, Department of Cancer Medicine, Imperial College of Science Technology and Medicine, MRC Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. (DRC, HB, OCH, PP, EOA)
Imaging Research Solutions Limited, MRC Cyclotron Building, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. (MG, SO, SKL, FB)
Department of Nuclear Medicine, University of Leipzig, Liebigstrasse 20A, 04103 Leipzig, Germany. (HB)
The Smurfit Institute of Genetics, Trinity College, Dublin, Ireland. (LBH, SJM)
Cancer Research UK Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey SM2 SNG, UK. (PW)
ID# 2446
Tags: Animals, Annexin A5/pharmacokinetics, Antineoplastic Antimetabolites/therapeutic use, Apoptosis, Cultured Tumor Cells, Deoxyadenosines/pharmacokinetics, Emission-Computed Tomography, Enzyme Inhibitors/pharmacokinetics, Experimental Sarcoma/drug therapy/metabolism/pathology/radionuclide imaging, Fibrosarcoma/drug therapy/metabolism/pathology/radionuclide imaging, Flow Cytometry, Fluorouracil/therapeutic use, Humans, In Situ Nick-End Labeling, In Vitro Techniques, Inbred C3H Mice, Iodine Radioisotopes/diagnostic use, Isotope Labeling/methods, Mice, Protein Binding, Thionucleosides/pharmacokinetics, Tissue Distribution