AnalyzeDirect Richards DA, Bao W, Rambo MV, Burgert M, Jucker BM, Lenhard SC. Examining the relationship between exercise tolerance and isoproterenol-based cardiac reserve in murine models of heart failure. J Appl Physiol (1985). May 2013;114(9):1202-1210.
Full Text – Open Access
Publication Date
May 2013
How Analyze was Used
“MRI was conducted 1 wk after each ETT [Exercise tolerance testing].”
“Images of the LV [left ventricle] were analyzed using Analyze (AnalyzeDirect, Overland Park, KS) to obtain end-systolic volume (ESV), end-diastolic volume (EDV), and LV volume, from which LV mass, stroke volume (SV), ejection fraction (%EF) and cardiac output (CO; via multiplication with HR) parameters were calculated.”
Keywords
Adrenergic beta-Agonists/diagnostic use
Animals
Cardiotonic Agents/diagnostic use
Disease Models, Animal
Exercise Test
Exercise Tolerance/physiology
Heart Failure/etiology/physiopathology
Humans
Isoproterenol/diagnostic use
Magnetic Resonance Imaging (MRI)
Male
Mice
Mice, Inbred C57BL
Myocardial Infarction/complications
Oxygen Consumption
Physical Exertion/physiology
Transverse Aortic Constriction
Treadmill
Ventricular Function, Left
Author Affiliation(s)
Heart Failure Discovery Performance Unit, Metabolic Pathways and Cardiovascular Therapy Area Unit, GlaxoSmithKline, King of Prussia, PA, US. (DAR, WB, BMJ, SCL)
University of Bristol, Bristol, Avon, UK. (DAR)
Laboratory Animal Sciences, GlaxoSmithKline, King of Prussia, PA, US. (MVR)
Statistical Consulting Group, GlaxoSmithKline, King of Prussia, PA, US. (MB)
Preclinical and Translational Imaging, GlaxoSmithKline, King of Prussia, PA, US. (BMJ, SCL)
ID# 57
Tags: Adrenergic beta-Agonists/diagnostic use, Animal Disease Models, Animals, Cardiotonic Agents/diagnostic use, Exercise Test, Exercise Tolerance/physiology, Heart Failure/etiology/physiopathology, Humans, Inbred C57BL Mice, Isoproterenol/diagnostic use, Left Ventricular Function, Magnetic Resonance Imaging (MRI), Male, Mice, Myocardial Infarction/complications, Oxygen Consumption, Physical Exertion/physiology, Transverse Aortic Constriction, Treadmill