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Degenerative knee joint disease in mice lacking 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis

Ford-Hutchinson AF, Ali Z, Seerattan RA, Cooper DML, Hallgrimsson B, Salo PT, Jirik FR. Degenerative knee joint disease in mice lacking 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis. Osteoarthritis Cartilage. May 2005;13(5):418-425.

Full Text – Open Access

Publication Date
May 2005

How Analyze was Used
“Three-dimensional (3D) volumetric renderings were produced using Analyze 5.0 (AnalyzeDirect, Lenexa, KS). Software provided with scanner was used to measure the 3D thickness distributions of the tibial plateaus, using a model-independent method [Hildebrand and Ruegsegger 1997].”

Keywords
Animals
Cartilage, Articular/pathology
Disease Models, Animal
Female
Femur/pathology
Fibula/pathology
Hindlimb
Joint Diseases/enzymology/pathology
Joints/pathology
Male
Mice
Mice, Inbred C57BL
Multienzyme Complexes/deficiency/genetics/metabolism
Mutation
Patella/pathology
Sulfate Adenylyltransferase/deficiency/genetics/metabolism
Tibia/pathology
Tomography, X-Ray Computed/methods

Author Affiliation(s)
Department of Biochemistry and Molecular Biology, The McCaig Center for Joint Injury and Arthritis Research, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. (AFFH, ZA, FRJ)

Department of Surgery, The McCaig Center for Joint Injury and Arthritis Research, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. (RAS, PTS)

Department of Archaeology and Medical Science, The McCaig Center for Joint Injury and Arthritis Research, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. (DMLC)

Department of Cell Biology and Anatomy, The McCaig Center for Joint Injury and Arthritis Research, University of Calgary, Calgary, Alberta, T2N 4N1, Canada. (BH)

ID# 2030

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