AnalyzeDirect

Korsisaari N, Ross J, Wu X, Kowanetz M, Pal N, Hall L, Eastham-Anderson J, Forrest WF, Van Bruggen N, Peale FV, Ferrara N. Blocking vascular endothelial growth factor-A inhibits the growth of pituitary adenomas and lowers serum prolactin level in a mouse model of multiple endocrine neoplasia type 1. Clin Cancer Res. January 2008;14(1):249-258.

Full Text – Open Access

Publication Date
January 2008

How Analyze was Used
“Primary pituitary tumor volumes were calculated from magnetic resonance imaging data using three-dimensional regions of interest drawn in Analyze software (AnalyzeDirect, Inc.).”

Keywords
Adenoma/blood/metabolism/pathology
Animals
Antibodies, Monoclonal/pharmacology
Disease Models, Animal
Immunohistochemistry
Magnetic Resonance Imaging (MRI)
Mice
Mice, Mutant Strains
Mice, Nude
Multiple Endocrine Neoplasia Type 1/blood/metabolism/pathology
Neovascularization, Pathologic
Pituitary Neoplasms/blood/metabolism/pathology
Prolactin/blood
Reverse Transcriptase Polymerase Chain Reaction
Vascular Endothelial Growth Factor A/antagonists & inhibitors/drug effects

Author Affiliation(s)
Genentech, Inc., South San Francisco, CA 94080, US.

ID# 1491

Tags: Adenoma/blood/metabolism/pathology, Animal Disease Models, Animals, Immunohistochemistry, Magnetic Resonance Imaging (MRI), Mice, Monoclonal Antibodies/pharmacology, Multiple Endocrine Neoplasia Type 1/blood/metabolism/pathology, Mutant Strains Mice, Nude Mice, Pathologic Neovascularization, Pituitary Neoplasms/blood/metabolism/pathology, Prolactin/blood, Reverse Transcriptase Polymerase Chain Reaction, Vascular Endothelial Growth Factor A/antagonists & inhibitors/drug effects