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Moulin-Sallanon M, Charnay Y, Ginovart N, Perret P, Lanfumey L, Hamon M, Hen R, Fagret D, Ibáñez V, Millet P. Acute and chronic effects of citalopram on 5-HT1A receptor-labeling by [¹⁸F]MPPF and -coupling to receptors-G proteins. Synapse. February 2009;63(2):106-116.

Full Text – Open Access

Publication Date
February 2009

How Analyze was Used
“A summed image between 1 and 30 min was obtained and data were analyzed using Analyze 8.0 software … to define anatomical regions of interest.”

Keywords
8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
Animals
Autoradiography
Brain/drug effects/metabolism/radionuclide imaging
Citalopram/pharmacology
Fluorine Radioisotopes/diagnostic use
Guanosine 5′-O-(3-Thiotriphosphate)/metabolism
Male
Mice
Mice, Knockout
Positron-Emission Tomography (PET)
Radiopharmaceuticals/diagnostic use
Rats
Rats, Wistar
Receptors, G-Protein-Coupled/metabolism
Receptors, Serotonin, 5-HT1/genetics/metabolism
Serotonin Receptor Agonists/pharmacology
Serotonin Uptake Inhibitors/pharmacology

Author Affiliation(s)
INSERM, Unit U877, J Fourier University, La Tronche, France. (MMS, PP, DF)

Department of Psychiatry, Psychiatric Neuroimaging Unit, University Hospital of Geneva, Geneva, Switzerland. (MMS, NG, VI, PM)

Department of Psychiatry, Morphology Unit, University Hospital of Geneva, Geneva, Switzerland. (YC)

Department of Psychiatry, University of Geneva, Geneva, Switzerland. (NG)

UMR U677 INSERM/UPMC, Faculty of Medicine Pierre et Marie Curie, Site Pitié-Salpêtrière, Paris, France. (LL, MH)

Center of Neurobiology and Behavior, Columbia University, New York, NY, US. (RH)

ID# 1346

Tags: 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology, Animals, Autoradiography, Brain/drug effects/metabolism/radionuclide imaging, Citalopram/pharmacology, Fluorine Radioisotopes/diagnostic use, G-Protein-Coupled Receptors/metabolism, Guanosine 5'-O-(3-Thiotriphosphate)/metabolism, Knockout Mice, Male, Mice, Positron Emission Tomography (PET), Radiopharmaceuticals/diagnostic use, Rats, Serotonin 5-HT1 Receptors/genetics/metabolism, Serotonin Receptor Agonists/pharmacology, Serotonin Uptake Inhibitors/pharmacology, Wistar Rats