Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, Pillai R, He Q, Atadja P, Lam EWF, Workman P, Vigushin DM, Aboagye EO. In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3′-deoxy-3′-[18F]fluorothymidine positron emission tomography. Cancer Res. August 2006;66(15):7621-7629.
Full Text – Open Access
Publication Date
August 2006
How Analyze was Used
“The image data sets obtained were transferred to a SUN workstation … and visualized using the Analyze software (version 6.0).”
Keywords
Animals
Cell Cycle/drug effects
Cell Growth Processes/drug effects
Colonic Neoplasms/drug therapy/enzymology/metabolism/radionuclide imaging
Dideoxynucleosides/diagnostic use/pharmacokinetics
Drug Interactions
Female
HCT116 Cells
Histone Deacetylase Inhibitors
Humans
Hydroxamic Acids/pharmacology
Mice
Mice, Inbred BALB C
Positron-Emission Tomography (PET)
RNA, Messenger/biosynthesis/genetics
Radiopharmaceuticals/diagnostic use/pharmacokinetics
Random Allocation
Thymidine Kinase/biosynthesis/genetics/metabolism
Xenograft Model Antitumor Assays
Author Affiliation(s)
Molecular Therapy, Imperial College London, Faculty of Medicine, Hammersmith Hospital, London, UK. (JL, JRL, MP, RP, EOA)
Cancer Cell Biology, Imperial College London, Faculty of Medicine, Hammersmith Hospital, London, UK. (JPA, MDC, AVS, EW-FL, DMV)
Department of Oncology, Clinical Research Laboratory, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden. (QH)
Novartis Institutes for Biomedical Research, Cambridge, MA, US. (PA)
Cancer Research United Kingdom Center for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey, UK. (PW)
ID# 1968
Tags: Animals, Cell Cycle/drug effects, Cell Growth Processes/drug effects, Colonic Neoplasms/drug therapy/enzymology/metabolism/radionuclide imaging, Dideoxynucleosides/diagnostic use/pharmacokinetics, Drug Interactions, Female, HCT116 Cells, Histone Deacetylase Inhibitors, Humans, Hydroxamic Acids/pharmacology, Inbred BALB C Mice, Messenger RNA/biosynthesis/genetics, Mice, Positron Emission Tomography (PET), Radiopharmaceuticals/diagnostic use/pharmacokinetics, Random Allocation, Thymidine Kinase/biosynthesis/genetics/metabolism, Xenograft Model Antitumor Assays