AnalyzeDirect Schopf L, Savinainen A, Anderson K, Kujawa J, DuPont M, Silva M, Siebert E, Chandra S, Morgan J, Gangurde P, Wen D, Lane J, Xu Y, Hepperle M, Harriman G, Ocain T, Jaffee B. IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis. Arthritis Rheum. October 2006;54(10):3163-3173.
Full Text – Open Access
Publication Date
October 2006
How Analyze was Used
“Raw micro-CT data were imported into the software package Analyze (AnalyzeDirect).”
Keywords
Animals
Arthritis, Experimental
Arthritis, Rheumatoid/chemically induced/metabolism/physiopathology
Bone and Bones/metabolism/pathology
Carbolines/pharmacology
Cartilage/metabolism/pathology
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Freund’s Adjuvant
Gene Expression Regulation
I-kappa B Kinase/antagonists & inhibitors/genetics/metabolism
NF-kappa B/genetics/metabolism
Niacinamide/analogs & derivatives/pharmacology
Rats
Rats, Inbred Lew
Tumor Necrosis Factor-alpha/metabolism
Author Affiliation(s)
Millennium Pharmaceuticals, Cambridge, MA, US.
ID# 1845
Tags: Animal Disease Models, Animals, Bone and Bones/metabolism/pathology, Carbolines/pharmacology, Cartilage/metabolism/pathology, Drug Dose-Response Relationship, Experimental Arthritis, Female, Freund's Adjuvant, Gene Expression Regulation, I-kappa B Kinase/antagonists & inhibitors/genetics/metabolism, Inbred Lew Rats, NF-kappa B/genetics/metabolism, Niacinamide/analogs & derivatives/pharmacology, Rats, Rheumatoid Arthritis/chemically induced/metabolism/physiopathology, Tumor Necrosis Factor-alpha/metabolism